{"title":"Structural character of α-syn12 peptide in solution at high pH","authors":"Lixia Liu","doi":"10.1109/ICIME.2010.5477473","DOIUrl":null,"url":null,"abstract":"The dynamics and structural character of a-syn12 peptide in aqueous solution at high pH has been investigated through temperature replica exchange molecular dynamics simulations by using GROMOS 43A1 force field. The isolated a-syn12 peptide adopts in water an a-helix structure at high pH. These results are distinct from other amyloid disease protein at neutral pH.","PeriodicalId":382705,"journal":{"name":"2010 2nd IEEE International Conference on Information Management and Engineering","volume":"24 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2010-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2010 2nd IEEE International Conference on Information Management and Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICIME.2010.5477473","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The dynamics and structural character of a-syn12 peptide in aqueous solution at high pH has been investigated through temperature replica exchange molecular dynamics simulations by using GROMOS 43A1 force field. The isolated a-syn12 peptide adopts in water an a-helix structure at high pH. These results are distinct from other amyloid disease protein at neutral pH.
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