Does Vitamin- D Have A Relation to Diabetic Peripheral Neuropathy in Egyptian Type 2 Diabetes Mellitus Patients?

Abstract

Objectives is to detect relation between vitamin D deficiency and increased risk of peripheral neuropathy in type 2 diabetes (DM). Methods The study included total number of 90 subjects; 60 cases with type 2 DM and was divided into two groups; one with peripheral neuropathy, the other group without peripheral neuropathy and 30 healthy subjects as control. All the included cases were subjected to full history taking, clinical examination (general and neurological), ocular fundus examination and laboratory investigations including Glomerular filtration rate (GFR), glycosylated hemoglobin (HbA1c), assessment of serum level of vitamin D was conducted to all cases. All the included subjects were examined to assess the degree of presence or absence of retinopathy. Results We found that HbA1c and hsCRP (high sensitivity C-reactive protein) level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with T2DM without peripheral neuropathy and control groups. The serum level of vitamin D was statistically significantly lower in those with peripheral neuropathy group in comparison to those without neuropathy and control groups. By multivariate regression analysis, DM duration, high values of HbA1c, urinary albumin/creatinine ratio (ACR), hs-CRP, systolic blood pressure (SBP) and decreased serum vitamin D levels were shown to be independent predictors for diabetic peripheral neuropathy. Conclusion Serum level of vitamin D was low in Egyptians Type 2 diabetes mellitus patients with neuropathy in comparison to those without