Euclides Nenga, Manuel Sacomboio, Sandra Alberto Pululo, C. Sebastião, Carlos Alberto, Pinto Sousa
Background Diabetes is a chronic disease characterized by alterations in glucose, lipid, and protein metabolism, which can be identified by detecting high blood glucose levels. In this study we evaluated the frequency of ABO/Rh blood groups in patients with diabetes treated in Luanda, during the second half of 2020. Methods This was an observational, analytical, prospective study with a quantitative approach conducted with 100 patients with diabetes. Results The mean age of patients was 48,4±14 years old. Patients males (63%) with a mean age of 47.9±14.5 years old, secondary educational level (33%), and living in urbanized areas from Luanda (33%), which were the most prevalent in this studied population. About 57% did not exercise before the disease and did not have the disease in the family (51%). About 71% of the patients used insulin to treat diabetes. ORh+ and ARh+ blood groups were the most frequent. The majority of the patients were less than 4 years with diabetes. Conclusion We concluded that the patients most affected by diabetes were the elderly, males, from urbanized areas, and with blood groups ORh+ or ARh+. Further studies assessing the relationship between ABO/Rh blood groups and diabetes among the Angolan population are needed.
{"title":"Frequency of ABO/Rh Blood Groups Among Patients with Diabetes Mellitus in Luanda, Angola","authors":"Euclides Nenga, Manuel Sacomboio, Sandra Alberto Pululo, C. Sebastião, Carlos Alberto, Pinto Sousa","doi":"10.33140/ijdmd.09.01.01","DOIUrl":"https://doi.org/10.33140/ijdmd.09.01.01","url":null,"abstract":"Background Diabetes is a chronic disease characterized by alterations in glucose, lipid, and protein metabolism, which can be identified by detecting high blood glucose levels. In this study we evaluated the frequency of ABO/Rh blood groups in patients with diabetes treated in Luanda, during the second half of 2020. Methods This was an observational, analytical, prospective study with a quantitative approach conducted with 100 patients with diabetes. Results The mean age of patients was 48,4±14 years old. Patients males (63%) with a mean age of 47.9±14.5 years old, secondary educational level (33%), and living in urbanized areas from Luanda (33%), which were the most prevalent in this studied population. About 57% did not exercise before the disease and did not have the disease in the family (51%). About 71% of the patients used insulin to treat diabetes. ORh+ and ARh+ blood groups were the most frequent. The majority of the patients were less than 4 years with diabetes. Conclusion We concluded that the patients most affected by diabetes were the elderly, males, from urbanized areas, and with blood groups ORh+ or ARh+. Further studies assessing the relationship between ABO/Rh blood groups and diabetes among the Angolan population are needed.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of this article is analyses the possible causes and provide a review of the literature of a large ulcerated lesions. We present the case of a 13-year-old girl who came to the oral medicine clinic, referred by her orthodontist, with a large round lesion on the ventral side of the tongue (15 x 12 mm) that did not heal, after three weeks of evolution and after eliminating the existing traumatic factors (orthodoctic appliance in the lower jaw) and treatment with topical gel based on PVP (polyvinyl pyrrolidone), glycyrrhetinic acid and hyaluronic acid (Aloclair PLUS®). Topical treatment with corticosteroids (clobetasol propionate) was considered to try to reduce the lesion, prior to biopsy. However, the decision of his maxillofacial surgeon to perform an excisional biopsy and subsequent histological study, seemed to us to be an appropriate approach. Conclusions: In oral pathology, the appearance of a large, ulcerated lesions may suggest a malignant process that requires an early diagnosis given the uneasiness of the patient and his or her family. Finding lingual carcinoma in children is, however, extremely rare.
本文旨在分析大面积溃疡性病变的可能原因，并对相关文献进行综述。我们介绍了一个 13 岁女孩的病例，她在牙齿矫正医生的推荐下来到口腔内科门诊就诊，她的舌头腹侧有一个巨大的圆形病灶（15 x 12 毫米），经过三周的演变，在消除了现有的创伤因素（下颌矫正器）并使用基于 PVP（聚乙烯吡咯烷酮）、甘草亭酸和透明质酸（Aloclair PLUS®）的外用凝胶治疗后，病灶仍未愈合。在活组织检查之前，曾考虑使用皮质类固醇（丙酸氯倍他索）进行局部治疗，以减轻病变。不过，颌面外科医生决定进行切除活检，并随后进行组织学研究，在我们看来这是一种适当的方法。结论：在口腔病理学中，大面积溃疡性病变的出现可能提示恶性过程，鉴于患者及其家人的不安，需要及早诊断。然而，在儿童中发现舌癌是极为罕见的。
{"title":"Eosinophilic Ulcer (tugse) On the Tongue: A Case Report.","authors":"","doi":"10.33140/ijdmd.08.03.03","DOIUrl":"https://doi.org/10.33140/ijdmd.08.03.03","url":null,"abstract":"The objective of this article is analyses the possible causes and provide a review of the literature of a large ulcerated lesions. We present the case of a 13-year-old girl who came to the oral medicine clinic, referred by her orthodontist, with a large round lesion on the ventral side of the tongue (15 x 12 mm) that did not heal, after three weeks of evolution and after eliminating the existing traumatic factors (orthodoctic appliance in the lower jaw) and treatment with topical gel based on PVP (polyvinyl pyrrolidone), glycyrrhetinic acid and hyaluronic acid (Aloclair PLUS®). Topical treatment with corticosteroids (clobetasol propionate) was considered to try to reduce the lesion, prior to biopsy. However, the decision of his maxillofacial surgeon to perform an excisional biopsy and subsequent histological study, seemed to us to be an appropriate approach. Conclusions: In oral pathology, the appearance of a large, ulcerated lesions may suggest a malignant process that requires an early diagnosis given the uneasiness of the patient and his or her family. Finding lingual carcinoma in children is, however, extremely rare.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139354916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Diabetes Mellitus is a conglomerate of metabolic alterations that chronically affect health. Neuropathy, previous ulcers, foot deformities, peripheral arterial disease, and chronic kidney disease are risk factors that predispose to the development of foot ulcers. It was carried out in order to determine risk factors for ulceration in people living with diabetes mellitus. Materials and methods: Descriptive observational study of 233 people who attended the Preventive Foot consultation at the Diabetes, Obesity and Specialties Medical Center, during the period January-April 2022. Information collected through a questionnaire that reported age, sex, marital status, time of diagnosis of diabetes mellitus, history of ulcer, amputation, bone deformity, chronic renal failure, neuropathy and peripheral arterial disease. Results: 60% female, 40% male, 60% ≥ 62 years. 39.6% with diagnosis time ≥16 years, 65.2%-foot deformity, 12.8% previous ulcer, 5.1% previous amputation, 10.3% chronic renal failure, 36% peripheral neuropathy and 31.3% peripheral arterial disease. 47.6% presented a very low risk, 27.5% moderate, 15% high risk and 9% low. Association time of diagnosis and neuropathy chi2= 8.993, p= <0.029. Ulcer and amputation correlation rho=0.606, p=< .001. Discussion: As risk factors predominated foot deformity, followed by diabetic neuropathy and peripheral arterial disease. With significant association between the time of diagnosis and neuropathy. With moderate direct proportional correlation between ulcer and previous amputation
{"title":"Risk Factors for Ulceration in Diabetes Mellitus in the Preventive Foot Clinic at the Medical Center for Diabetes, Obesity, and Specialties, During the Period January-April 2022.","authors":"","doi":"10.33140/ijdmd.08.03.04","DOIUrl":"https://doi.org/10.33140/ijdmd.08.03.04","url":null,"abstract":"Introduction: Diabetes Mellitus is a conglomerate of metabolic alterations that chronically affect health. Neuropathy, previous ulcers, foot deformities, peripheral arterial disease, and chronic kidney disease are risk factors that predispose to the development of foot ulcers. It was carried out in order to determine risk factors for ulceration in people living with diabetes mellitus. Materials and methods: Descriptive observational study of 233 people who attended the Preventive Foot consultation at the Diabetes, Obesity and Specialties Medical Center, during the period January-April 2022. Information collected through a questionnaire that reported age, sex, marital status, time of diagnosis of diabetes mellitus, history of ulcer, amputation, bone deformity, chronic renal failure, neuropathy and peripheral arterial disease. Results: 60% female, 40% male, 60% ≥ 62 years. 39.6% with diagnosis time ≥16 years, 65.2%-foot deformity, 12.8% previous ulcer, 5.1% previous amputation, 10.3% chronic renal failure, 36% peripheral neuropathy and 31.3% peripheral arterial disease. 47.6% presented a very low risk, 27.5% moderate, 15% high risk and 9% low. Association time of diagnosis and neuropathy chi2= 8.993, p= <0.029. Ulcer and amputation correlation rho=0.606, p=< .001. Discussion: As risk factors predominated foot deformity, followed by diabetic neuropathy and peripheral arterial disease. With significant association between the time of diagnosis and neuropathy. With moderate direct proportional correlation between ulcer and previous amputation","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139355546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Early blight is one of the major diseases of tomatoes that affects the leaves and fruit quality. Detection and estimation of the disease severity are performed using the visual observation method. Visual detection requires significant time for visual inspection of a large cultivated area. Thus, image processing techniques have proven to be an effective method as compared to visual analysis. In this study, digital image processing methods and techniques were used to detect early blight of tomato (EBT), estimate the disease severity, and classify tomato leaves. Totally, 198 infected plants were randomly taken from the Haramaya University research site "Rare" at four different times. Diseased potato leaf images were captured, resized, and stored for experimentation. The stored images were processed using median filtering to remove noise while preserving useful features in an image and image enhancement. The RGB images were transformed to gray scale and CIELAB color space, and the k-means clustering was applied to estimate the disease severity of the potato leaves, and Otsu’s thresholding algorithm was applied to estimate the disease severity of both the detached and live leaves. MATLAB algorithms will be developed to determine the total area and infected lesion area of the leaf samples.
{"title":"Detection of Early Blight Tomato Leaf Using k-Means Clustering","authors":"","doi":"10.33140/ijdmd.08.03.01","DOIUrl":"https://doi.org/10.33140/ijdmd.08.03.01","url":null,"abstract":"Early blight is one of the major diseases of tomatoes that affects the leaves and fruit quality. Detection and estimation of the disease severity are performed using the visual observation method. Visual detection requires significant time for visual inspection of a large cultivated area. Thus, image processing techniques have proven to be an effective method as compared to visual analysis. In this study, digital image processing methods and techniques were used to detect early blight of tomato (EBT), estimate the disease severity, and classify tomato leaves. Totally, 198 infected plants were randomly taken from the Haramaya University research site \"Rare\" at four different times. Diseased potato leaf images were captured, resized, and stored for experimentation. The stored images were processed using median filtering to remove noise while preserving useful features in an image and image enhancement. The RGB images were transformed to gray scale and CIELAB color space, and the k-means clustering was applied to estimate the disease severity of the potato leaves, and Otsu’s thresholding algorithm was applied to estimate the disease severity of both the detached and live leaves. MATLAB algorithms will be developed to determine the total area and infected lesion area of the leaf samples.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139363712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatitis is a viral infection that causes inflammation of the liver. However, other factors can cause the disease, including secondary effects from drugs, toxins, alcohol, and autoimmune hepatitis. The autoimmune form of the disease occurs when the body produces antibodies against the liver tissue, and many people worldwide are affected by it. Various clinical factors and parameters are examined in diagnosing hepatitis disease, which is analyzed by performing various tests of these factors and parameters. As a result of the vastness of the parameters under examination, it is challenging and complicated for the experts in this field to perform the analysis process on these parameters on a large scale. Healthcare experts can now identify the factors influencing the death rate of patients with high speed and accuracy thanks to emerging technologies such as machine learning, which is a subset of artificial intelligence. In this study, KNN and SVM machine learning techniques were used to analyze the positive effect of clinical parameters such as LIVER BIG, LIVER FIRM, SPLEEN PALPABLE, and ANOREXIA on patients' survival or death rates. This study investigates and analyzes the results of the implementation in two parts. The first part deals with determining the positive impact of these clinical parameters on the death and survival rate of patients, and the second part examines the performance of machine learning techniques based on the evaluation criteria of accuracy (ACC), error rate (ERR), specificity (SPE), and negative prediction value (NPV).Based on the implementation finding of machine learning techniques on data related to hepatitis patients, it has been determined that patients with positive LIVER BIG, LIVER FIRM, SPLEEN PALPABLE, and ANOREXIA clinical parameters can have a high chance of survival. On the other side, The SVM technique outperformed the KNN technique by ACC 94.05%, ERR 16.02%, SPE 93.07%, and NPV 85.7% in an analysis of the performance of machine learning techniques.
{"title":"Clinical Usefulness of Machine Learning Approaches as a Non-Invasive Technology in Reducing Hepatitis Disease Mortality","authors":"","doi":"10.33140/ijdmd.08.03.02","DOIUrl":"https://doi.org/10.33140/ijdmd.08.03.02","url":null,"abstract":"Hepatitis is a viral infection that causes inflammation of the liver. However, other factors can cause the disease, including secondary effects from drugs, toxins, alcohol, and autoimmune hepatitis. The autoimmune form of the disease occurs when the body produces antibodies against the liver tissue, and many people worldwide are affected by it. Various clinical factors and parameters are examined in diagnosing hepatitis disease, which is analyzed by performing various tests of these factors and parameters. As a result of the vastness of the parameters under examination, it is challenging and complicated for the experts in this field to perform the analysis process on these parameters on a large scale. Healthcare experts can now identify the factors influencing the death rate of patients with high speed and accuracy thanks to emerging technologies such as machine learning, which is a subset of artificial intelligence. In this study, KNN and SVM machine learning techniques were used to analyze the positive effect of clinical parameters such as LIVER BIG, LIVER FIRM, SPLEEN PALPABLE, and ANOREXIA on patients' survival or death rates. This study investigates and analyzes the results of the implementation in two parts. The first part deals with determining the positive impact of these clinical parameters on the death and survival rate of patients, and the second part examines the performance of machine learning techniques based on the evaluation criteria of accuracy (ACC), error rate (ERR), specificity (SPE), and negative prediction value (NPV).Based on the implementation finding of machine learning techniques on data related to hepatitis patients, it has been determined that patients with positive LIVER BIG, LIVER FIRM, SPLEEN PALPABLE, and ANOREXIA clinical parameters can have a high chance of survival. On the other side, The SVM technique outperformed the KNN technique by ACC 94.05%, ERR 16.02%, SPE 93.07%, and NPV 85.7% in an analysis of the performance of machine learning techniques.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Idiopathic hypercalciuria is associated to urinary stone formation and bone loss and should be treated not only to prevent kidney stone formation but also to prevent fragility fractures. Thiazide diuretics are traditionally used to control hypercalciuria. indapamide, a sulfonamide thiazide diuretic, with some differences in structure is similar in its mechanisms of action such as its hypocalciuric effect, and bone density protection, with less adverse metabolic consequences than other thiazides such as less hypokalemia and hypotension. We evaluated efficacy and adverse effects of indapamide in 88 idiopathic hypercalciuric consecutive patients and only those who reached normal calciuria in the first 9 months, were followed during two years. Changes in bone turn-over markers and bone density were evaluated. Since year one, there was a significant lowering of urine calcium to normal values in 77 patients, with no change in sodium excretion. There were changes in bone turn over markers and gains in bone mineral density according to the groups analyzed. In 25 hypercalciuric osteoporotic patients, there was a significant increment in lumbar spine bone density at year 2 of follow-up, (p<0.05). Those hypercalciuric osteoporotic stone former patients had a significant increase in femoral neck bone density since year one. Adverse effects were not significant, no changes found in blood pressure, glycemia, cholesterol, serum uric acid, sodium and potassium. Two patients needed potassium supplementation for mild hypokalemia and did not stop indapamide. In conclusion indapamide is an effective alternative treatment to Idiopathic hypercalciuria, controlling calcium loss and bone density for at least two years.
{"title":"Indapamide Effects on Hypercalciuria and Bone Mineral Density","authors":"","doi":"10.33140/ijdmd.07.02.19","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.19","url":null,"abstract":"Idiopathic hypercalciuria is associated to urinary stone formation and bone loss and should be treated not only to prevent kidney stone formation but also to prevent fragility fractures. Thiazide diuretics are traditionally used to control hypercalciuria. indapamide, a sulfonamide thiazide diuretic, with some differences in structure is similar in its mechanisms of action such as its hypocalciuric effect, and bone density protection, with less adverse metabolic consequences than other thiazides such as less hypokalemia and hypotension. We evaluated efficacy and adverse effects of indapamide in 88 idiopathic hypercalciuric consecutive patients and only those who reached normal calciuria in the first 9 months, were followed during two years. Changes in bone turn-over markers and bone density were evaluated. Since year one, there was a significant lowering of urine calcium to normal values in 77 patients, with no change in sodium excretion. There were changes in bone turn over markers and gains in bone mineral density according to the groups analyzed. In 25 hypercalciuric osteoporotic patients, there was a significant increment in lumbar spine bone density at year 2 of follow-up, (p<0.05). Those hypercalciuric osteoporotic stone former patients had a significant increase in femoral neck bone density since year one. Adverse effects were not significant, no changes found in blood pressure, glycemia, cholesterol, serum uric acid, sodium and potassium. Two patients needed potassium supplementation for mild hypokalemia and did not stop indapamide. In conclusion indapamide is an effective alternative treatment to Idiopathic hypercalciuria, controlling calcium loss and bone density for at least two years.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116619208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The antioxidant efficacy of tender and mature coconut water of Cocos nucifera fruit was studied to ascertain the potential effects of the liquid on some biochemical indices. Materials and Methods: In vitro antioxidants activity was carried out on the coconut water using DPPH assay, ferric ion reducing antioxidant power assay (FRAP), and phosphomolybdenum assay (PM). Twenty albino rats (80 – 120 g) divided into 5 groups of 4 rats each were used for this study. Group 1 served as the normal control while groups 2-5 were induced with diabetes using 120 mg/kg b.w. alloxan monohydrate. Group 2 was untreated while Group 3 was treated with glibenclamide. Groups 4 and 5 were treated with 1 ml/kg b.w of mature coconut water and tender coconut water respectively. Results: Both tender and mature coconut water and that of the standard (ascorbic acid) showed a concentration-dependent DPPH scavenging capacity. The liquid also reduced the ferric ion in a concentration-dependent manner. Both tender and matured coconut water reduced Phosphate-Mo (VI) to Phosphate Mo (V) in a concentration-dependent manner. Malondialdehyde concentration (MDA) decreased significantly (p<0.05) when compared to group 2. The in vivo antioxidant status (CAT, GSH, Vitamin C, and Vitamin E) showed a significant (p<0.05) increase unlike group 2 while SOD activity showed significant (p < 0.05) increase in group 2. Conclusion: The results obtained from this study showed that both tender and mature coconut water have potent antioxidant properties and as such can reduce the complications associated with diabetes mellitus.
{"title":"Effect of Coconut Water on Lipid Peroxidation and Some Antioxidant Status of Diabetic Rats","authors":"","doi":"10.33140/ijdmd.07.02.12","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.12","url":null,"abstract":"Aim: The antioxidant efficacy of tender and mature coconut water of Cocos nucifera fruit was studied to ascertain the potential effects of the liquid on some biochemical indices. Materials and Methods: In vitro antioxidants activity was carried out on the coconut water using DPPH assay, ferric ion reducing antioxidant power assay (FRAP), and phosphomolybdenum assay (PM). Twenty albino rats (80 – 120 g) divided into 5 groups of 4 rats each were used for this study. Group 1 served as the normal control while groups 2-5 were induced with diabetes using 120 mg/kg b.w. alloxan monohydrate. Group 2 was untreated while Group 3 was treated with glibenclamide. Groups 4 and 5 were treated with 1 ml/kg b.w of mature coconut water and tender coconut water respectively. Results: Both tender and mature coconut water and that of the standard (ascorbic acid) showed a concentration-dependent DPPH scavenging capacity. The liquid also reduced the ferric ion in a concentration-dependent manner. Both tender and matured coconut water reduced Phosphate-Mo (VI) to Phosphate Mo (V) in a concentration-dependent manner. Malondialdehyde concentration (MDA) decreased significantly (p<0.05) when compared to group 2. The in vivo antioxidant status (CAT, GSH, Vitamin C, and Vitamin E) showed a significant (p<0.05) increase unlike group 2 while SOD activity showed significant (p < 0.05) increase in group 2. Conclusion: The results obtained from this study showed that both tender and mature coconut water have potent antioxidant properties and as such can reduce the complications associated with diabetes mellitus.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130437657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective We aimed to evaluate potential gender differences in serum levels of oxidized low-density lipoprotein (ox-LDL) in patients with type 2 diabetes (T2D) and controls. We looked at the correlation between ox-LDL levels and 10-year cardiovascular disease (CVD) risk using Framingham risk score. Materials and Methods A total of 454 (268 women) patients with T2D and 140 (107 women) participants without T2D were recruited for this study. Ox-LDL, lipid profile, glycemic indices, anthropometric measurements, and 10-year CVD risk score were compared among the subgroups. Results In participants without T2D, women had lower levels of ox-LDL in comparison with men (33.94±6.48 U/L vs. 59.54±14.36 U/L; adjusted odds ratio (OR) of 0.968 (95% confidence interval (CI), 0.947-0.990). However, in participants with T2D, oxLDL levels were higher in women compared to men (92.11±38.07 U/L vs. 79.18±34.63 U/L; adjusted OR of 1.008 (95%CI, 1.001-1.014). In addition, in female participants without T2D, ox-LDL levels in post-menopausal women were higher than the pre-menopausal ones (38.48±6.48 U/L vs. 29.66±5.16 U/L; adjusted OR of 1.036 (95%CI, 1.005-1.068). In contrast, this difference disappeared in female participants with T2D (92.08±39.40 U/L vs. 91.38±34.73 U/L; adjusted OR of 0.999 (95%CI, 0.994-1.024). Moreover, after controlling for potential confounders, the 10-year CVD risk score had a significant association with ox-LDL levels in men without T2D (R=0.899, p ≤0.001), women without T2D (R=0.318, p=0.012), men with T2D (R= 0.446, p=0.003) and women with T2D (R= 0.298, p=0.001). Conclusions Participants with T2D had higher levels of ox-LDL compared to the controls. Moreover, among participants with T2D, the levels of ox-LDL increased more adversely in women than men. T2D may override the effect of gender and menopausal status on ox-LDL.
目的评估2型糖尿病(T2D)患者和对照组血清氧化低密度脂蛋白(ox-LDL)水平的潜在性别差异。我们使用Framingham风险评分来观察ox-LDL水平与10年心血管疾病(CVD)风险之间的相关性。材料和方法本研究共招募了454例(268名女性)T2D患者和140例(107名女性)非T2D参与者。比较各亚组之间的Ox-LDL、血脂、血糖指数、人体测量值和10年心血管疾病风险评分。结果在没有T2D的参与者中，女性的ox-LDL水平低于男性(33.94±6.48 U/L vs. 59.54±14.36 U/L;校正优势比(OR)为0.968(95%可信区间(CI)， 0.947-0.990)。然而，在t2dm患者中，女性的oxLDL水平高于男性(92.11±38.07 U/L vs. 79.18±34.63 U/L;调整OR为1.008 (95%CI, 1.001-1.014)。此外，在没有T2D的女性参与者中，绝经后女性的ox-LDL水平高于绝经前女性(38.48±6.48 U/L vs. 29.66±5.16 U/L;调整OR为1.036 (95%CI, 1.005-1.068)。相比之下，这种差异在女性T2D患者中消失(92.08±39.40 U/L vs. 91.38±34.73 U/L;调整OR为0.999 (95%CI, 0.994-1.024)。此外，在控制潜在混杂因素后，10年CVD风险评分与无T2D的男性(R=0.899, p≤0.001)、无T2D的女性(R=0.318, p=0.012)、有T2D的男性(R= 0.446, p=0.003)和有T2D的女性(R= 0.298, p=0.001)的ox-LDL水平显著相关。结论:与对照组相比，T2D患者的ox-LDL水平较高。此外，在患有T2D的参与者中，女性的ox-LDL水平比男性增加得更不利。T2D可能超越性别和绝经状态对ox-LDL的影响。
{"title":"Gender-Related Differences of Oxidized Low-Density Lipoprotein Levels in Adults with and without Type 2 Diabetes","authors":"","doi":"10.33140/ijdmd.07.02.22","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.22","url":null,"abstract":"Objective We aimed to evaluate potential gender differences in serum levels of oxidized low-density lipoprotein (ox-LDL) in patients with type 2 diabetes (T2D) and controls. We looked at the correlation between ox-LDL levels and 10-year cardiovascular disease (CVD) risk using Framingham risk score. Materials and Methods A total of 454 (268 women) patients with T2D and 140 (107 women) participants without T2D were recruited for this study. Ox-LDL, lipid profile, glycemic indices, anthropometric measurements, and 10-year CVD risk score were compared among the subgroups. Results In participants without T2D, women had lower levels of ox-LDL in comparison with men (33.94±6.48 U/L vs. 59.54±14.36 U/L; adjusted odds ratio (OR) of 0.968 (95% confidence interval (CI), 0.947-0.990). However, in participants with T2D, oxLDL levels were higher in women compared to men (92.11±38.07 U/L vs. 79.18±34.63 U/L; adjusted OR of 1.008 (95%CI, 1.001-1.014). In addition, in female participants without T2D, ox-LDL levels in post-menopausal women were higher than the pre-menopausal ones (38.48±6.48 U/L vs. 29.66±5.16 U/L; adjusted OR of 1.036 (95%CI, 1.005-1.068). In contrast, this difference disappeared in female participants with T2D (92.08±39.40 U/L vs. 91.38±34.73 U/L; adjusted OR of 0.999 (95%CI, 0.994-1.024). Moreover, after controlling for potential confounders, the 10-year CVD risk score had a significant association with ox-LDL levels in men without T2D (R=0.899, p ≤0.001), women without T2D (R=0.318, p=0.012), men with T2D (R= 0.446, p=0.003) and women with T2D (R= 0.298, p=0.001). Conclusions Participants with T2D had higher levels of ox-LDL compared to the controls. Moreover, among participants with T2D, the levels of ox-LDL increased more adversely in women than men. T2D may override the effect of gender and menopausal status on ox-LDL.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131130595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives is to detect relation between vitamin D deficiency and increased risk of peripheral neuropathy in type 2 diabetes (DM). Methods The study included total number of 90 subjects; 60 cases with type 2 DM and was divided into two groups; one with peripheral neuropathy, the other group without peripheral neuropathy and 30 healthy subjects as control. All the included cases were subjected to full history taking, clinical examination (general and neurological), ocular fundus examination and laboratory investigations including Glomerular filtration rate (GFR), glycosylated hemoglobin (HbA1c), assessment of serum level of vitamin D was conducted to all cases. All the included subjects were examined to assess the degree of presence or absence of retinopathy. Results We found that HbA1c and hsCRP (high sensitivity C-reactive protein) level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with T2DM without peripheral neuropathy and control groups. The serum level of vitamin D was statistically significantly lower in those with peripheral neuropathy group in comparison to those without neuropathy and control groups. By multivariate regression analysis, DM duration, high values of HbA1c, urinary albumin/creatinine ratio (ACR), hs-CRP, systolic blood pressure (SBP) and decreased serum vitamin D levels were shown to be independent predictors for diabetic peripheral neuropathy. Conclusion Serum level of vitamin D was low in Egyptians Type 2 diabetes mellitus patients with neuropathy in comparison to those without
{"title":"Does Vitamin- D Have A Relation to Diabetic Peripheral Neuropathy in Egyptian Type 2 Diabetes Mellitus Patients?","authors":"","doi":"10.33140/ijdmd.07.02.11","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.11","url":null,"abstract":"Objectives is to detect relation between vitamin D deficiency and increased risk of peripheral neuropathy in type 2 diabetes (DM). Methods The study included total number of 90 subjects; 60 cases with type 2 DM and was divided into two groups; one with peripheral neuropathy, the other group without peripheral neuropathy and 30 healthy subjects as control. All the included cases were subjected to full history taking, clinical examination (general and neurological), ocular fundus examination and laboratory investigations including Glomerular filtration rate (GFR), glycosylated hemoglobin (HbA1c), assessment of serum level of vitamin D was conducted to all cases. All the included subjects were examined to assess the degree of presence or absence of retinopathy. Results We found that HbA1c and hsCRP (high sensitivity C-reactive protein) level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with T2DM without peripheral neuropathy and control groups. The serum level of vitamin D was statistically significantly lower in those with peripheral neuropathy group in comparison to those without neuropathy and control groups. By multivariate regression analysis, DM duration, high values of HbA1c, urinary albumin/creatinine ratio (ACR), hs-CRP, systolic blood pressure (SBP) and decreased serum vitamin D levels were shown to be independent predictors for diabetic peripheral neuropathy. Conclusion Serum level of vitamin D was low in Egyptians Type 2 diabetes mellitus patients with neuropathy in comparison to those without","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115469256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monzer azhari mahgoub farah, Rahel Gebreab Mahari, Inshah Malik
Background: Febrile seizure (FS) is one of the most common neurologic disorders in children. Electrolyte imbalance especially hyponatremia may have an important role in triggering the febrile seizure. The measure of serum electrolytes will be useful in predicting further seizures. This study aimed to investigate the effect of relative hyponatremia on the risk of recurrent febrile seizures. Methods: This prospective study was performed on 115 children (6-60 months) with convulsions, at the pediatric department of Ibrahim malik teaching hospital. the serum sodium was measured immediately after abortion of seizures and each patient was followed for 24 hours for assessment of recurrence. Of the 115 children, 47 (40.9 %) develop recurrent febrile seizures. Of those the majority were males 36 (76.6%) (P=0.01), 52(45.2%) age less than 12 months(P=0.001), 26 (68.4%) have parents’ consanguinity(P=0.000), and were first born child25 (53.2%). The mean serum sodium levels in patients with one and recurrent attacks, were 132.1, 136.1 meq/l, respectively (P=0.00). Conclusions: The serum sodium level was ominously lower in the recurrence group compared to the non-recurrent group. Measurements of serum sodium levels and hyponatremia diagnosis have a key role in predicting the FC recurrence. Therefore, doctors should be careful during fluid administration to febrile seizure patients.
{"title":"Low Serum Sodium Level and Prediction of Febrile Seizure Recurrence","authors":"Monzer azhari mahgoub farah, Rahel Gebreab Mahari, Inshah Malik","doi":"10.33140/ijdmd.07.02.15","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.15","url":null,"abstract":"Background: Febrile seizure (FS) is one of the most common neurologic disorders in children. Electrolyte imbalance especially hyponatremia may have an important role in triggering the febrile seizure. The measure of serum electrolytes will be useful in predicting further seizures. This study aimed to investigate the effect of relative hyponatremia on the risk of recurrent febrile seizures. Methods: This prospective study was performed on 115 children (6-60 months) with convulsions, at the pediatric department of Ibrahim malik teaching hospital. the serum sodium was measured immediately after abortion of seizures and each patient was followed for 24 hours for assessment of recurrence. Of the 115 children, 47 (40.9 %) develop recurrent febrile seizures. Of those the majority were males 36 (76.6%) (P=0.01), 52(45.2%) age less than 12 months(P=0.001), 26 (68.4%) have parents’ consanguinity(P=0.000), and were first born child25 (53.2%). The mean serum sodium levels in patients with one and recurrent attacks, were 132.1, 136.1 meq/l, respectively (P=0.00). Conclusions: The serum sodium level was ominously lower in the recurrence group compared to the non-recurrent group. Measurements of serum sodium levels and hyponatremia diagnosis have a key role in predicting the FC recurrence. Therefore, doctors should be careful during fluid administration to febrile seizure patients.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116514806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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