Could juice from Viburnum opulus potentially prevent the formation of kidney stones? (an anımal study)

Abstract

The principal objective of this inquiry was to explore the potential impact of Viburnum opulus L. fruit juice in mitigating the occurrence of kidney stone formation within a rat model induced experimentally to develop kidney stones. Twenty Sprague Dawley rats were used in the study. They were placed in metabolic cages, with one rat per cage. Urine samples were collected every day during the study period. Biochemıcal values were measured in urine and blood. The rats were sacrificed, and their kidneys were removed and evaluated histopathologically after staining with Hematoxylin-Eosin (HE) and Pizzolato's (PZ) staining methods. The biochemical parameters observed in the urine samples collected from the experimental group of rats exhibited more excellent proximity to the negative control group's corresponding values than those of the positive control group. Upon microscopic examination of histological sections, a notable resemblance in histological architecture was discerned between the experimental and negative control groups. Additionally, a reduction in the incidence of stone formation was observed in the experimental group when contrasted with the positive control group. In light of the outcomes elucidated herein, it can be deduced that the administration of Viburnum opulus (VO) water engenders an augmenting impact on citrate levels. This elevation in citrate concentration holds potential significance as it demonstrates the potential to curtail crystal formation. Notably, citrate ions exhibit an inhibitory role in the genesis of calcium oxalate (CaOx) crystals, thereby contributing to the prevention.