Analysis of The Deformation in Red Blood Cells Based on The Transmembrane Voltage Potential and The Pore Density

Abstract

This paper presents the response of different type of Red Blood cells to an applied electric pulse. Different electroporation parameters are presented based on a mathematical model that uses the whole membrane of normal and malignant red blood cells. Different parameters can be extracted from the analysis of the electroporation of a biological cell, such as the deformation rate of its membrane and its electroporation response. This paper focuses on two main features to differ between the normal and malignant red blood cells. These features are the membrane potential and the density of the pores as a response for an applied electric field. Also, this paper presents a COMSOL Model which is used to solve both the membrans’s transmembrane potential and the distribution of the pores across it.