Advances in the Planning and Control of the MR-guided Regional Hyperthermia Applications

J. Nadobny, M. Weihrauch, M. Weiser, J. Gellermann, W. Wlodarczyk, V. Budach, P. Wust
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Abstract

A novel method for improved planning and control of the magnetic resonance (MR)-guided hyperthermia (HT) has been developed and tested in the combined Berlin MR-HT hybrid system, consisting of the 12-channel HT applicator Sigma-Eye and of the MR tomograph Siemens MAGNETOM Symphony 1.5 T. The method is based on a step-by-step adaptation of antenna profiles (single antenna fields) using MR temperature rise measurements obtained by the proton resonance frequency shift (PRFS) method. A Gauss-Newton algorithm is applied as an iterative solver for adaptation. It is shown that, using the finite-difference time-domain (FDTD) method as initial estimate for antenna profiles, already after few adaptation steps a significant improvement of the specific absorption rate (SAR) predictability in the MR-HT hybrid system is reached.
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核磁共振引导局部热疗应用的规划与控制研究进展
一种改进规划和控制磁共振(MR)引导热疗(HT)的新方法已经开发并在柏林MR-HT混合系统中进行了测试,该系统由12通道HT应用器Sigma-Eye和MR断层成像仪Siemens MAGNETOM Symphony 1.5 t组成。该方法基于使用质子共振频移(PRFS)方法获得的MR温升测量值逐步适应天线轮廓(单天线场)。采用高斯-牛顿算法作为自适应迭代求解器。结果表明,采用时域有限差分(FDTD)方法作为天线轮廓的初始估计,在经过几个自适应步骤后,MR-HT混合系统的比吸收率(SAR)可预测性得到了显著提高。
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