EVALUATION OF THE EFFECTIVENESS OF DENTAL COMPLACATIONS PREVENTION AGAINST THE BACKGROUND OF CHEMOTHERAPY IN ONCOLOGICAL PATIENTS IN ZAPORIZHZHIA

Abstract

SUMMARY. The aim – to investigate the condition of the oral cavity in patients with malignant neoplasms of the mammary gland and lungs before and after chemotherapy and to analyze the effectiveness of dental prophylaxis. Material and methods. To achieve this goal, a statistical study of oncological patients undergoing chemotherapy at the ONCOLIFE medical center (Zaporizhzhia) was performed. 60 patients, both men and women, were enrolled in the study. All respondents were divided into groups according to cancer type: group 1 consisted of 30 lung cancer patients, group 2 comprised 30 breast cancer patients, and group 3, the control group, included 30 people without cancer. Research results have been processed with modern statistical methods on a PC with Statistica 13 software package. Results. The data were checked for normality of distribution since the distribution of most data differs from normal; the median and interquartile range (Me(Q25; Q75)) of data presentation were designed. A comparison of indicators in three independent groups was performed with the Kruskall – Wallis test, in two independent groups – with the Mann – Whitney test, and the non-parametric Wilcoxon test was used to determine the effect of prophylactic treatment. The Chi-square test was used to compare qualitative data. Differences were considered statistically significant at a significance level of p<0.05. Conclusions. Patients with oncopathology accompanied with unsatisfactory oral hygiene, caries and its complications are more likely to get dental problems during chemotherapy treatment. Oncological patients diagnosed with lung cancer and breast cancer developed relatively similar dental complications, which confirms the negative effect of chemotherapy treatment as is.