M Campbell, A M Small, C S Hollander, J Korein, I L Cohen, M Kalmijn, S Ferris
{"title":"A controlled crossover study of triiodothyronine in autistic children.","authors":"M Campbell, A M Small, C S Hollander, J Korein, I L Cohen, M Kalmijn, S Ferris","doi":"10.1007/BF01538042","DOIUrl":null,"url":null,"abstract":"<p><p>A placebo-controlled crossover study of behavioral effects of triiodothyronine (T3) was conducted in 30 young clinically euthyroid autistic children. Multiple independent raters and multiple rating scales were used. Except for a few symptoms that were reduced on T3, the drug did not differ from placebo. Time itself accounted for most of the improvement in the whole sample. As a group, the lower IQ children responded to T3. The individual children who were responders could not be defined by any parameter.</p>","PeriodicalId":15139,"journal":{"name":"Journal of autism and childhood schizophrenia","volume":"8 4","pages":"371-81"},"PeriodicalIF":0.0000,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01538042","citationCount":"37","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of autism and childhood schizophrenia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01538042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 37
Abstract
A placebo-controlled crossover study of behavioral effects of triiodothyronine (T3) was conducted in 30 young clinically euthyroid autistic children. Multiple independent raters and multiple rating scales were used. Except for a few symptoms that were reduced on T3, the drug did not differ from placebo. Time itself accounted for most of the improvement in the whole sample. As a group, the lower IQ children responded to T3. The individual children who were responders could not be defined by any parameter.
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