Bacterial Resistance of Acinetobacter baumannii: A Global Concern

Abstract

Acinetobacter baumannii (A. baumannii), one of the five most important bacteria with global threat to human health due to constantly increasing resistance (ESKAPE organisms), identified as a enormous threat in healthcare facilities, can create antibiotic resistance. The implementation of early detection and identification of multidrug-resistant A. baumannii is serious to control its spread. The this study presents the human infection of A. baumannii, pathological findings, virulence factors of A. baumannii, antibiotic resistance mechanisms, and the therapeutic options available for treating A. baumannii infections. The ability of A. baumannii to develop antibiotic resistance mechanisms allows the organism to prosper in hospital settings, facilitating the global spread of multidrug-resistant strains. To dominate this problem, knowledge of the pathogenesis and antibiotic resistance mechanisms of A. baumannii is important. As reported, A. baumannii resistance to aminoglycosides, fluoroquinolones, and carbapenems increased, and resistance to lipopeptides, such as polymyxin B and colistin, are lower compared to that of other antimicrobial drugs. Therefore, novel prevention and treatment strategies against A. baumannii infections are warranted.