Cell Microinjection Device Suitable for Curved Needle Based on Triangular Flexible Mechanism

Abstract

Existing microinjection needles are curved needles, but most of the current cell injection devices are designed for straight needles. In addition, the existing microinjection needle causes large lateral vibration when the membrane is broken. Although lateral vibration is also considered as an important condition for cell membrane rupture, large lateral vibration will cause great damage to the cells and reduce the success rate of cell injection. To a certain extent, it has formed a contradiction with the rapid development of modern biomedicine. To this end, this paper proposes a micro-injection needle suitable for curved needles based on a triangular flexible mechanism, which can greatly reduce the lateral vibration during cell injection, and plays a guiding role in axial. It is also suitable for the more popular injection bending needle. Simulation results show that the microinjection needle can obtain less lateral vibration and more stable axial vibration.