Liver Metastases Pattern in Rectal Cancer: A Real-World Analysis in the SEER Database

Abstract

Background: The liver is a common metastatic site of colorectal cancer. Rectal cancer patients with organ metastases are more liable to show poor prognosis. The hazard and forecast elements of liver metastases are need to be estimated in rectal cancer patients. Methods: The data of newly diagnosed patients of rectal cancer with liver metastases are evaluated according to Surveillance, Epidemiology, and End Results (SEER) program between 2010 and 2016. The Overall Survival (OS) for dierent subgroups are appraised by Kaplan-Meier analysis and log-rank tests. Univariate and multivariable logistic analysis and Cox regression are performed to evaluate predictors and elements of the presence of liver metastases in new diagnosis, respectively. Results: There are a total of 6,662 (11.1%) rectal cancer patients paired with liver metastases. Factors including age (below), gender (female), marital status (unmarried), race (black), advanced T or N classification, presence of bone or lung metastases, and the absence of surgical treatments are importantly related to the occurrence of liver metastases. The median survival for liver metastases rectal cancer patients was 16.0 months. Indicators referring to elder age, black race, unmarried status, presence of bone, brain or lung metastases, and the absence of surgical treatments all predicted worse survival. Conclusion: The data of our research provide corresponding risks and prognostic elements for liver metastases rectal cancer patients, which offer a way to predict the occurrence of rectal cancer and guide prophylactic treatment in clinical settings.