Preliminary updating on structural and chemotaxonomical aspects of pharmacologically evaluated flavonoids

Abstract

Abstract. This communication presents a preliminary update on pharmacologically evaluated flavonoids under several aspects including: (i) structure-structure associations, (ii) structure-plant affiliations and (iii) structure-activity trends. Although pharmacological evaluations are continuously performed on secondary metabolites, a small fraction of published (elucidated) molecules were revealed to be concerned with lab testing. This resulted in strongly sparse information in literature that did not favor integrative work in this field. While sparse data don’t favor intensive analysis of well target system (e.g. a given pharmacological activity of a given metabolic family associated with a given plant taxon), big sets of cumulated data from many origins provide alternative way for extensive analysis helping to highlight backbone information on target biochemical system. This principle was applied to highlight different structural, functional and chemotaxonomical aspects of pharmacologically evaluated flavonoids.