Antioxidant and antidiabetic activity of Andrographis paniculata and Rhinacanthus nasutus in isoniazid and rifampicin induced Wistar rats

Abstract

The present investigation aimed to identify the effects of ethanolic extract of Andrographis paniculata Linn. and Rhinacanthus nasutus Kurz. on enzymatic and non-enzymatic antioxidants on isoniazid and rifampicin induced Wistar rats. Animals were randomly divided into nine groups of 6 rats each and housed in individually ventilated cages for further experimental procedure. The levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-s-transfersase (GST), lipid peroxides (LPO), reduced glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and carbohydrate metabolism parameters of glucose, glycogen, glucose-6-phosphatase, glucose-6-phosphatase dehydrogenase and hexokinase are estimated at the end of the study. The present study results highlighted that the leaves extract of A. paniculata and R. nasutus have an antioxidant effect and anti-diabetic activity against the toxin treated rats.