SYNTHESIS ,CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY OF SOME HETEROCYCLIC COMPOUNDS

Abstract

Heterocycles are an important class of organic compounds because of their applications in medicines and industrial fields. Therefore our study included preparation of these compound such as oxazepine and quinazoline rings, which were prepared through two steps: The first step included the reaction of the Schiff bases derived from sulfamethaxazole (1-4) with each of phthalic anhydride and 3- nitrophthalic anhydride for the preparation of oxazepines (5-12) .While the second step included the preparation of quinazoline compounds (13-16) from the reaction of Schiff bases (1-4) with anthranilic acid using dry benzene as a medium and solvent for the reaction. All prepared compounds were characterized by using infrared,proton- nuclear magnetic resonance, mass techniques and melting points, and their purity was determined by thin layer chromatography technique also screened the biological activity of some of these prepared compounds by using two types of bacteria Gram-positive and negative . The results showed that these compounds have a good inhibition against these organisms