Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens

Proceedings of the International Conference on Natural Resources and Technology Pub Date : 1900-01-01 DOI:10.5220/0008506300870090

Adelya Irawan Manalu, I. Jamilah, S. Lenny

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Abstract

Quorum-sensing is a specific communication type among microbial species, exposing several virulence factors to host or internal environment. The phenomenon is currently being studied as potential target for drug discovery and development. Natural product derived from plant source may be evaluated as potential quorum-sensing inhibitor (QSI). The study aimed to determine the optimum concentration of Andaliman methanolic (MeOH) and ethyl acetate extract (EtOAc) against prodigiosin synthesis by Serratia marcescens as one of phenotypes controlled by quorum sensing. Based on optical density (OD600), both extracts did not interfere with the growth of microorganism. The optimum concentration of MeOH extract in inhibiting the prodigiosin synthesis was at concentration of 0.05% (w/v) in the end of incubation period (30 h). Meanwhile, the EtOAc extract inhibit the prodigiosin synthesis at concentration of 0.4% in the end of incubation period. Our results showed that Andaliman possess natural products as QSI which needed further evaluation in the future.

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安达利曼(Zanthoxylum acanthopodium DC.)的效力粘质沙雷菌群体感应抑制剂提取物研究

群体感应是微生物物种之间的一种特殊的交流方式，它将多种毒力因子暴露于宿主或内部环境中。目前正在研究这种现象，作为药物发现和开发的潜在目标。植物源天然产物可能被评价为潜在的群体感应抑制剂(QSI)。本研究旨在确定安达利曼甲醇(MeOH)和乙酸乙酯提取物(EtOAc)的最佳浓度，以抑制粘质沙雷氏菌(Serratia marcescens)合成芥子红素。基于光密度(OD600)，两种提取物均未干扰微生物的生长。在孵育结束(30 h)时，MeOH提取物的最佳抑制浓度为0.05% (w/v)，而在孵育结束时，EtOAc提取物的抑制浓度为0.4%。结果表明，安达曼属天然产物可作为QSI，有待进一步评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the International Conference on Natural Resources and Technology

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