{"title":"Targeting Endothelial SIRT1 for the Prevention of Arterial Aging","authors":"Yumeng Guo, Yu Wang","doi":"10.5772/INTECHOPEN.73019","DOIUrl":null,"url":null,"abstract":"Cardiovascular diseases are the leading cause of morbidity and mortality in the elderly population all over the world. Arterial aging is the earliest manifestation and a key risk factor for age-induced cardiovascular abnormalities. The longevity regulator Sirtuin 1 (SIRT1) is abundantly expressed in the endothelium of the arteries and elicits potent protective functions against arterial aging. Targeting endothelial SIRT1 represents a promising approach for the prevention and treatment of cardiovascular diseases. This chapter provides an overview of SIRT1’s regulation and function in endothelial cells and discusses the potential applica- tions of targeting endothelial SIRT1 for arterial aging-related cardiovascular diseases.","PeriodicalId":254860,"journal":{"name":"Endothelial Dysfunction - Old Concepts and New Challenges","volume":"20 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endothelial Dysfunction - Old Concepts and New Challenges","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5772/INTECHOPEN.73019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Cardiovascular diseases are the leading cause of morbidity and mortality in the elderly population all over the world. Arterial aging is the earliest manifestation and a key risk factor for age-induced cardiovascular abnormalities. The longevity regulator Sirtuin 1 (SIRT1) is abundantly expressed in the endothelium of the arteries and elicits potent protective functions against arterial aging. Targeting endothelial SIRT1 represents a promising approach for the prevention and treatment of cardiovascular diseases. This chapter provides an overview of SIRT1’s regulation and function in endothelial cells and discusses the potential applica- tions of targeting endothelial SIRT1 for arterial aging-related cardiovascular diseases.
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