Prevalence and Predictors of Coronary Artery Ectasia among Delta Population

Mohamed Mahmoud El-Shawadfy, A. El-Sheikh, Sahar Abdullah El-Shedoudy, M. Ashmawy
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Abstract

Background: Localized or widespread non-obstructive lesions of the epicardial coronary arteries, with a luminal dilatation 1.5 times that of the neighbouring normal segments or vessel diameter, have been identified as CAE. This research was performed to determine prevalence and predictors of CAE among Delta population in Egypt. Methods: This cross-sectional research was conducted on 2850 cases over the age of 18 who came for coronary angiography with positive non-invasive diagnostic tests, acute coronary syndrome and stable CAD. Cases were divided into two groups Group I: CAE cases (n =108) and Group II Non-ectasia cases (n =2742). All cases were subjected to history taking, clinical examination, laboratory investigations, standard 12-leads ECG, resting transthoracic echocardiography (TTE) and coronary angiography. Results: CAE occurred in 108 (3.79%) of the studied cases. Total cholesterol level, serum creatinine, were insignificantly different between both groups. CRP, NLR, MPV, and PLR, were significantly higher in CAE cases versus non-Ectasia cases CRP, NLR, PLR, and MPV is a good predicator for CAE, LVESD and LVEDD, were significantly higher in CAE group. Conclusions: The RCA was the most often affected coronary artery. The existence of CAE can be predicted using easily accessible clinical laboratory values such as CRP, Neutrophil to lymphocyte ratio, mean platelet volume, and platelet to lymphocyte ratio.
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三角洲人群冠状动脉扩张的患病率及预测因素
背景:心外膜冠状动脉局部或广泛的非阻塞性病变,其管腔扩张是邻近正常节段或血管直径的1.5倍,已被确定为CAE。本研究旨在确定埃及三角洲地区人群中CAE的患病率和预测因素。方法:对非侵入性诊断检查阳性、急性冠状动脉综合征、冠心病稳定的18岁以上行冠状动脉造影的2850例患者进行横断面研究。病例分为两组:第一组:CAE病例(n =108)和第二组:非扩张病例(n =2742)。所有病例均接受病史记录、临床检查、实验室检查、标准12导联心电图、静息经胸超声心动图(TTE)及冠状动脉造影检查。结果:CAE发生率为108例(3.79%)。两组总胆固醇水平、血清肌酐差异无统计学意义。CRP、NLR、MPV和PLR在CAE组显著高于非扩张组,CRP、NLR、PLR和MPV是CAE、LVESD和LVEDD的良好预测指标,CAE组显著高于非扩张组。结论:RCA是最常见的冠状动脉。CAE的存在可以通过易于获得的临床实验室值来预测,如CRP、中性粒细胞与淋巴细胞比值、平均血小板体积、血小板与淋巴细胞比值。
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