Computational Design of a Personalized Artificial Spinal Disc for Additive Manufacturing With Physiological Rotational Motions

Zhiyang Yu, T. Stanković, K. Shea
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Abstract

Due to the limitations of currently available artificial spinal discs stemming from anatomical unfit and unnatural motion, patient-specific elastomeric artificial spinal discs are conceived as a promising solution to improve clinical results. Multimaterial Additive Manufacturing (AM) has the potential to facilitate the production of an elastomeric composite artificial disc with complex personalized geometry and controlled material distribution. Motivated by the potential combined advantages of personalized artificial spinal discs and multi-material AM, a biomimetic multi-material elastomeric artificial disc design with several matrix sections and a crisscross fiber network is proposed in this study. To determine the optimized material distribution of each component for natural motion restoration, a computational method is proposed. The method consists of automatic generation of a patient-specific disc Finite Element (FE) model followed by material property optimization. Biologically inspired heuristics are incorporated into the optimization process to reduce the number of design variables in order to facilitate convergence. The general applicability of the method is verified by designing both lumbar and cervical artificial discs with varying geometries, natural rotational motion ranges, and rotational stiffness requirements. The results show that the proposed method is capable of producing a patient-specific artificial spinal disc design with customized geometry and optimized material distribution to achieve natural spinal rotational motions. Future work focuses on extending the method to also include implant strength and shock absorption behavior into the optimization as well as identifying a suitable AM process for manufacturing.
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基于生理旋转运动的增材制造个性化人工椎间盘计算设计
由于目前可用的人工椎间盘由于解剖学上的不合适和不自然的运动而受到限制,患者特异性弹性人工椎间盘被认为是改善临床结果的有希望的解决方案。多材料增材制造(AM)有可能促进具有复杂个性化几何形状和受控材料分布的弹性体复合人工盘的生产。基于个性化人工椎间盘和多材料AM潜在的综合优势,本研究提出了一种具有多个基体截面和纵横交错纤维网络的仿生多材料弹性人工椎间盘设计。为了确定自然运动恢复中各部件的最佳材料分布,提出了一种计算方法。该方法包括自动生成患者特定的椎间盘有限元模型,然后进行材料性能优化。生物启发的启发式被纳入优化过程,以减少设计变量的数量,以促进收敛。通过设计具有不同几何形状、自然旋转运动范围和旋转刚度要求的腰椎和颈椎人工椎间盘,验证了该方法的一般适用性。结果表明,该方法能够产生具有定制几何形状和优化材料分布的患者特异性人工椎间盘设计,以实现自然的脊柱旋转运动。未来的工作重点是扩展该方法,将植入物强度和减震行为纳入优化,并确定适合制造的增材制造工艺。
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