Pharmaceutical Significance of Oxotungsten and Oxochromium Complexes of Schiff Bases Derived from Thiosemicarbazones

Abstract

The thiosemicarbazones of bis(5-chlorosalicylaldehyde), bis(trifluoroacetylacetone), and their complexes with oxotungsten and oxochromium have been produced as metal complexes. These complexes have been identified by their IR, electronic, molar, and magnetic moment spectra. These studies have shown that the metal ion is surrounded by an octahedral geometry. Additionally, the complexes were examined for potential medicinal uses. Microbial agents acquiring drug resistant tendencies, have infected human beings, this research explores synthesis and characterization of these Schiff base metal complexes showing biological properties and were evaluated for their in-vitro anti-microbial activity. Antibacterial activity was examined by agar plate diffusion technique. Antifungal properties were examined by the radial growth method using agar-agar culture. The results show that activity increases on chelation. This activity is affected by the nature of substituents. This in relation to the lipophilicity of the ligands and their membrane permeability, is a key factor in determining their entry inside the cell.