Development of biomineralization solutions to facilitate the transformation of brushite (CaHPO4·2H2O) into octacalcium phosphate (Ca8(HPO4)2(PO4)4·5H2O)

2010 15th National Biomedical Engineering Meeting Pub Date : 2010-04-21 DOI:10.1109/BIYOMUT.2010.5479865

Giray Girişken, A. Tas

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引用次数: 2

Abstract

Brushite (DCPD, CaHPO₄·2H₂O, dicalcium phosphate dihydrate) and octacalcium phosphate (OCP, Ca₈(HPO₄)₂(PO₄)₄·5H₂O) are two important biomineralization phases of the musculoskeletal system of living vertebrates which respectively crystallize in the very first instants of hard tissue formation accompanied by calcification, and then transform into the so-called bone mineral named as calcium-deficient hydroxyapatite (CDHA, Ca_10-x(HPO₄)_x(PO₄)_6-x(OH)_2-x). The utilization of these two phases in the surgical treatment of bone defects and voids has lately been the focus of interest of a significant number of research projects. Although the synthesis of DCPD is quite easy and reproducible, the same cannot be said for that of OCP. Biomineralization solutions which use DCPD as the starting material and can allow the economical transformation of DCPD into OCP have been developed in this study. This paper explains the preparation conditions of these solutions and elucidates the X-ray diffraction and infrared spectroscopy data of the phases formed.

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促进毛刷石(CaHPO4·2H2O)转化为磷酸八钙(Ca8(HPO4)2(PO4)4·5H2O)的生物矿化溶液的开发

刷石(DCPD, CaHPO4·2H2O，磷酸二氢钙)和磷酸八钙(OCP, Ca8(HPO4)2(PO4)4·5H2O)是活体脊椎动物肌肉骨骼系统中两个重要的生物矿化阶段，它们分别在硬组织形成的最初阶段结晶并伴有钙化，然后转化为所谓的骨矿物，称为缺钙羟基磷灰石(CDHA, Ca10-x(HPO4)x(PO4)6-x(OH)2-x)。在骨缺损和骨空洞的外科治疗中利用这两个阶段最近已成为许多研究项目感兴趣的焦点。虽然DCPD的合成很容易，重现性也很好，但OCP的合成就不一样了。本研究开发了以DCPD为起始材料的生物矿化解决方案，并可以将DCPD经济地转化为OCP。本文阐述了这些溶液的制备条件，并对所形成的相的x射线衍射和红外光谱数据进行了说明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2010 15th National Biomedical Engineering Meeting

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