The relationship of secretory phospholipase A2 type IIA levels with glomerulus filtration rate in type 2 DM patients

Abstract

Phospolipase / sPLA2 type IIA is mediator that connects pathogenesis diabetes and its complications. Diabetic nephropathy is the most frequent microvascular complications, with albumin urine and changes in glomerular filtration rate. The aim was to discover the relation between sPLA2 type IIA levels in diabetic patients with glomerular filtration rate (GFR). This study used crossectional method in 62 samples in RSJ. Prof. Dr. Soerojo Magelang. Sampling was done by total sampling and medical record used as instrument. This research conducted in patients with sPLA2 type IIA levels and has complete laboratory examination data carried out in 2016. The results showed that the level of sPLA2 type IIA was very high in diabetic patients and GFR was below normal. Pearson correlation analysis showed that there was no significant correlation between type IIA sPLA2 with GFR (p=0.318), with a positive but very weak correlation (r=0.129) with diabetic duration of 8 years. Pearson correlation analysis was conducted in 21 samples which GFR values were ≤60 (p=0.0712) resulted a negative direction (r=-0.086) with diabetes duration of 11 years. It was shown that diabetic patients with increased the level of sPLA2 type IIA and longer period of diabetes will affect the decrease in GFR value.