{"title":"Chemical stimulation of Aplysia californica ganglion with microfluidic signal generators","authors":"F. Azizi, C. Mastrangelo, Hui Lu, H. Chiel","doi":"10.1109/BIOCAS.2008.4696935","DOIUrl":null,"url":null,"abstract":"We implemented a microfluidic signal generator chip for the in-vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The PDMS chip implements a one-bit pulse-code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in inducing a burst of ingestive patterns.","PeriodicalId":415200,"journal":{"name":"2008 IEEE Biomedical Circuits and Systems Conference","volume":"22 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2008 IEEE Biomedical Circuits and Systems Conference","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIOCAS.2008.4696935","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
We implemented a microfluidic signal generator chip for the in-vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The PDMS chip implements a one-bit pulse-code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in inducing a burst of ingestive patterns.
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