Serum Levels of Copeptin are Decreased in Gestational Diabetes Mellitus

T. Ebert, M. Platz, S. Kralisch, U. Lossner, B. Jessnitzer, J. Richter, M. Blüher, M. Stumvoll, M. Fasshauer
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引用次数: 7

Abstract

Abstract Objective: Copeptin, the c-terminal part of pro-Arginine vasopressin, has recently been introduced as a novel risk factor to develop facets of the metabolic syndrome. However, regulation of copeptin in pregnancy-associated metabolic disease, i. e., gestational diabetes mellitus (GDM), has not been fully understood, so far. Patients and Measurements: For this study, 74 GDM patients and 74 healthy, pregnant, age-, body mass index-, and gestational age-matched controls were recruited. Serum levels of copeptin were quantified by an illuminometric assay. Furthermore, copeptin concentrations were correlated to biochemical and anthropometric markers of obesity, glucose and lipid metabolism, renal function, and inflammation. Results: Median [interquartile range] serum copeptin levels were significantly lower in subjects with GDM (3.5 [2.0] pmol/l) as compared to controls (4.4 [3.2] pmol/l) (p<0.05). Furthermore, GDM remained an independent predictor of circulating copeptin in multivariate regression analysis (p<0.05). Moreover, copeptin was independently associated with gestational age at blood sampling (p<0.05). Conclusions: Copeptin serum levels are significantly lower in GDM as compared to healthy pregnant controls. Further studies are needed to better clarify the pathophysiological role of copeptin in GDM.
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妊娠期糖尿病患者血清Copeptin水平降低
摘要目的:Copeptin是前精氨酸抗利尿激素的c端部分,最近被认为是代谢综合征发展的一个新的危险因素。然而,copeptin在妊娠相关代谢性疾病中的调节作用,如:妊娠期糖尿病(GDM),到目前为止尚未完全了解。患者和测量:本研究招募了74名GDM患者和74名健康、怀孕、年龄、体重指数和胎龄匹配的对照组。用光照测定法测定血清copeptin水平。此外,copeptin浓度与肥胖、糖脂代谢、肾功能和炎症等生化和人体测量指标相关。结果:GDM患者血清copeptin水平中位数[四分位数范围](3.5 [2.0]pmol/l)显著低于对照组(4.4 [3.2]pmol/l) (p<0.05)。此外,在多变量回归分析中,GDM仍然是循环copeptin的独立预测因子(p<0.05)。copeptin与采血时胎龄独立相关(p<0.05)。结论:GDM患者血清Copeptin水平明显低于健康孕妇对照组。copeptin在GDM中的病理生理作用有待进一步研究。
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