Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?

Waking and sleeping Pub Date : 1979-07-01
M S Myslobodsky, R Mansour
{"title":"Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?","authors":"M S Myslobodsky,&nbsp;R Mansour","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Systemic administration of GABA-transaminase inhibitors, gamma-acetylenic GABA (100 mg/kg) or gamma-vanylic GABA (1200 mg/kg) produces behavioral picture of somnolence accompanied by EEG hypersynchronisation reminiscent of electrographic signs of petit mal epilepsy. Similarly, systemic administration of GABA antagonist, Picrotoxin (3--4 mg/kg) produces a short lasting period of sedation preceding the development of myoclonic jerks which is also accompanied by Wave-spike discharges. The role of GABA in sleep control is discussed. Although the area is not ready for firm conclusions, the results suggest that hyperactivity of GABA-ergic system as well as its hypoactivity could mediate pathological somnolence associated with different forms of epilepsy.</p>","PeriodicalId":76817,"journal":{"name":"Waking and sleeping","volume":"3 3","pages":"245-54"},"PeriodicalIF":0.0000,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Waking and sleeping","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Systemic administration of GABA-transaminase inhibitors, gamma-acetylenic GABA (100 mg/kg) or gamma-vanylic GABA (1200 mg/kg) produces behavioral picture of somnolence accompanied by EEG hypersynchronisation reminiscent of electrographic signs of petit mal epilepsy. Similarly, systemic administration of GABA antagonist, Picrotoxin (3--4 mg/kg) produces a short lasting period of sedation preceding the development of myoclonic jerks which is also accompanied by Wave-spike discharges. The role of GABA in sleep control is discussed. Although the area is not ready for firm conclusions, the results suggest that hyperactivity of GABA-ergic system as well as its hypoactivity could mediate pathological somnolence associated with different forms of epilepsy.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
GABA-转氨酶抑制剂和微毒素产生的超同步和镇静作用:GABA是否参与睡眠控制?
全身服用GABA-转氨酶抑制剂、γ -乙基GABA(100毫克/公斤)或γ -戊基GABA(1200毫克/公斤)会产生嗜睡的行为图像,并伴有脑电图高度同步,使人想起小癫痫的电图迹象。同样,全身性给药GABA拮抗剂Picrotoxin (3- 4mg /kg)可在肌阵挛性抽搐发生前产生短暂持续的镇静作用,并伴有波峰放电。讨论了GABA在睡眠控制中的作用。虽然这一领域还不能得出确切的结论,但结果表明,gaba -能系统的多活性及其低活性可能介导与不同形式癫痫相关的病理性嗜睡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Age-specific doses of lormetazepam as a night sedative in cases of chronic sleep disturbance. Does para-chlorophenylalanine produce disturbed waking, disturbed sleep or activation by ponto-geniculo-occipital waves in cats? Mood and Sleep. I. Effects of the menstrual cycle. Mood and sleep. II. Effects of aversive pre-sleep stimulation. Flow microfluorometric study of cell kinetics of different tissues in ground squirrels (Citellus suslicus) during hibernation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1