[The significance of immunological constellation with regard to the development of hypersensitivity against various chemical compounds (author's transl)].

Abstract

Biopon is a generally used detergent containing detergens which does not cause hypersensitivity as was demonstrated by the authors in previous animal experiments. In the present study the authors describe the Haptene character of Biopon which quality could be demonstrated by causing a certain immunological constellation in guinea-pigs on the grounds of a hypothesis. The hypothetical concept consisted in aiding a half-antigen in the organism even in the case of its intradermal injection into a thick immunocompetent cell agglomeration. The authors produced the agglomeration of cells of the skin by means of intradermal injections of alien serum and in with BCG treated animals with tuberculin reaction. Biopon was administered thereafter into the focus by intradermal injection. The presented two aiding methods showed different effects which the authors try to explain by the fact that different adjuvants cause different effects.