A factor isolated from Datura stramonium that affects learning retention in mice

A. Ungerer , F. Schuber , R. Chauvin
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引用次数: 4

Abstract

A water-soluble fraction, devoid of alkaloids, was isolated from Datura stramonium (leaves and seeds). This fraction greatly impaired retention of (i) discriminated avoidance learning, (ii) two-way active avoidance learning, and (iii) a food-reinforced instrumental learning. The retention impairment induced by the Datura extract in these learning tasks was not due to an effect on spontaneous locomotor activity nor to changes in the emotional reactivity of the animals. Preliminary chemical analysis suggests that the active principle of the Datura extract may be a small peptide. It is suggested that this active principle affects some memory processes.

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从曼陀罗中分离出的影响小鼠学习记忆的因子
从曼陀罗叶和种子中分离出不含生物碱的水溶性组分。这个分数极大地损害了(i)区分回避学习,(ii)双向主动回避学习和(iii)食物强化工具性学习的保留。曼陀罗提取物在这些学习任务中引起的记忆障碍不是由于对自发运动活动的影响,也不是由于动物情绪反应的改变。初步化学分析表明,曼陀罗提取物的活性成分可能是一种小肽。这一活跃原理可能影响某些记忆过程。
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