Assess The Potential Protective Effect of Germinated Tiger Nuts on Some Biochemical and Histopathological Markers in Hepatotoxicity Rats

Abstract

A current study was undertaken to evaluate the potential hepatoprotective effect of germinated tiger nuts (GTNs) on the betterment of some biochemical and histopathological markers in hepatotoxicity rats. Fifty rats (200±7g) were exploited and haphazardly separated into five groups (n=7). Group 1 was employed as a negative control group (normal rats). Group 2 (positive control group) was injected intraperitoneal (IP) with CCl 4 at a dose of 2 ml/kg of b. wt. once/week for 6 weeks and fed on the basal diet lone. The remaining three groups (3, 4 and 5) were IP with 2 ml/kg of b.wt. of CCL 4 once/week (6 weeks) and fed on the prepared diet with GTNs at levels of 5, 10 and 15% respectively. In comparison with the normal rats, positive rats have a significant decrease in body weight (BW), relative body weight gain (RBWG%) and feed consumed (FC), as well as activity of CAT, SOD and GPx enzymes in liver tissues. There is a significant increase in serum levels of AST, ALT, ALP, albumin, Cr, UN, UA, total lipids, TG and TC, as