Molecular Oncology Of Colorectal Cancers Prognosis And Prediction, Radiation Oncologist Perspective

Abstract

Colorectal cancers (CRC) are a common cancer globally. The commonest symptoms were rectal bleeding (57%), pain (44%), and altered bowel habits (26%). 13 percent of the patients of colorectal cancer found signet ring tumor Histopathology which shows poor outcome of this very tumor , The CEA (Carcinoembryonic antigen) level estimation in patient serum commonly perform, surgery is a backbone of treatment unless until contraindicating factors are present after surgery tissue specimen required to send for not only histopathological studies rather also to look for tumor Immunohistochemistry studies in order to plan colorectal cancer very well directed chemotherapy according to its receptor as well as genetic or epigenetic alterations in BRAF, K-RAS, MMR, Most patients had localized or locally advanced disease. Twenty-eight percent of the patients had metastatic disease with liver being the commonest site of metastases (14%) followed by peritoneum and lung. More than half of the patients received treatment with a curative intent. Colorectal cancer in India differs from data than what we have found in data from western countries, In India we had more young patients, higher proportion of signet ring carcinomas, and more patients presenting with an advanced stage.