Antiproliferative activity of the CGA-containing SiO2/PEG hybrids synthesized by sol-gel method

THE 9TH INTERNATIONAL CONFERENCE ON STRUCTURAL ANALYSIS OF ADVANCED MATERIALS - ICSAAM 2019 Pub Date : 2019-12-12 DOI:10.1063/1.5140282

E. Tranquillo, I. Blanco, M. Catauro, Alessia Salzillo, L. Capasso, M. Illiano, Luigi Sapio, S. Naviglio

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Abstract

The delivery systems are able to maintain the drug concentration over time and increases duration of therapeutic activity of the active compound compared to the typical method of the administration of the drugs. Using the sol-gel method, it is possible to synthesized biomaterial implants as drug delivery systems. In this work, hybrid materials containing silica as inorganic matrix, with 6wt% of polyethylene glycol (PEG) and Chlorogenic acid (CGA) (5 and 10 wt %) were synthesized by sol-gel method. The biocompatibility, antibacterial properties and antiproliferative properties on different cells line were evaluated according to the CGA amount in the hybrids.The delivery systems are able to maintain the drug concentration over time and increases duration of therapeutic activity of the active compound compared to the typical method of the administration of the drugs. Using the sol-gel method, it is possible to synthesized biomaterial implants as drug delivery systems. In this work, hybrid materials containing silica as inorganic matrix, with 6wt% of polyethylene glycol (PEG) and Chlorogenic acid (CGA) (5 and 10 wt %) were synthesized by sol-gel method. The biocompatibility, antibacterial properties and antiproliferative properties on different cells line were evaluated according to the CGA amount in the hybrids.

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溶胶-凝胶法合成含cga的SiO2/PEG杂化物的抗增殖活性

与给药的典型方法相比，递送系统能够随时间维持药物浓度并增加活性化合物治疗活性的持续时间。利用溶胶-凝胶法，可以合成生物材料植入体作为给药系统。本文采用溶胶-凝胶法合成了以二氧化硅为无机基体，聚乙二醇(PEG)质量分数为6wt%，绿原酸(CGA)质量分数为5wt %和10wt %的杂化材料。根据CGA含量对不同细胞系的生物相容性、抗菌性能和抗增殖性能进行评价。与给药的典型方法相比，递送系统能够随时间维持药物浓度并增加活性化合物治疗活性的持续时间。利用溶胶-凝胶法，可以合成生物材料植入体作为给药系统。本文采用溶胶-凝胶法合成了以二氧化硅为无机基体，聚乙二醇(PEG)质量分数为6wt%，绿原酸(CGA)质量分数为5wt %和10wt %的杂化材料。根据CGA含量对不同细胞系的生物相容性、抗菌性能和抗增殖性能进行评价。

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THE 9TH INTERNATIONAL CONFERENCE ON STRUCTURAL ANALYSIS OF ADVANCED MATERIALS - ICSAAM 2019

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