Feedback control of blood pressure evaluations by a simple mechanical device

Abstract

Reducing the venous return in proportion to the blood pressure (BP) can prevent abnormal elevations of the latter. The possibility of applying this principle is examined for either permanent or acute control of a high BP. An implantable extravascular device based on this principle was applied in four dogs. One animal survived up to the 12th day and another was sacrificed in the 6th week. An external intravascular version was applied in four dogs. After setting the average BP to around 100 mm Hg, the device mitigated a metaraminol-induced BP elevation from about 240 to about 150 mm Hg without reducing BP when the hypertensive stimulus subsided.<>