High-Fat Diets-Induced Metabolic Disorders to Study Molecular Mechanism of Hyperlipidemia in Rats

Harfi Maulana, A. Ridwan
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引用次数: 1

Abstract

Hyperlipidemia is a lipid metabolism disorder occurring due to consumption of a high-fat diet (HFD), which contributes to atherosclerosis and cardiovascular disease development. HFD causes metabolic problems in Rodentia animals like human metabolic abnormalities, making it a popular model for studying the signaling systems involved. Hyperlipidemia is a condition in which the body's cholesterol levels elevate. In recent years, several studies have investigated the relationship between HFD feeding and hyperlipidemia and signaling pathways involved in cholesterol homeostasis. However, this signaling mechanism in lipid metabolism has not been fully explained, so additional analysis is needed. The present study aimed to investigate the mechanism that occurs from hyperlipidemia due to HFD feeding. The method used is a literature review approach following the PRISMA scheme for selecting the primary literature, including identification, screening, eligibility test, and inclusion. Eleven articles included primary literature with credibility (H-index) of 20, 33, 71, 92, 93, 162, 180, 192, and 332 (six articles from Q1 journals and five from Q2 journals). Long-term administration of HFD directly affects lipid metabolism, including an increase in the concentration of total cholesterol, triglycerides, LDL, and a decrease in HDL concentration, followed by an increase in body weight. In addition, HFD also disrupts adipose tissue and insulin resistance. The conclusion of this study is that HFD can cause hyperlipidemia either directly or indirectly by inducing insulin resistance, which contributes to lipid metabolism disorders.  
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高脂饮食诱导代谢紊乱研究大鼠高脂血症的分子机制
高脂血症是由于高脂肪饮食(HFD)引起的脂质代谢紊乱,有助于动脉粥样硬化和心血管疾病的发展。HFD在啮齿类动物中引起代谢问题,如人类代谢异常,使其成为研究相关信号系统的流行模型。高脂血症是体内胆固醇水平升高的一种情况。近年来,一些研究探讨了HFD饲喂与高脂血症的关系以及参与胆固醇稳态的信号通路。然而,脂质代谢中的这种信号机制尚未完全解释,因此需要进一步的分析。本研究旨在探讨高脂饮食引起高脂血症的发生机制。采用文献回顾法,按照PRISMA方案选择主要文献,包括鉴定、筛选、资格检验和纳入。11篇文章包括主要文献,可信度(h指数)分别为20、33、71、92、93、162、180、192和332(6篇文章来自Q1期刊,5篇来自Q2期刊)。长期服用HFD直接影响脂质代谢,包括总胆固醇、甘油三酯、LDL浓度升高,HDL浓度降低,随后体重增加。此外,HFD还会破坏脂肪组织和胰岛素抵抗。本研究的结论是HFD可直接或间接通过诱导胰岛素抵抗导致高脂血症,从而导致脂质代谢紊乱。
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