S. Matić, N. Srećković, Jelena Katanić Stanković, V. Mihailović
{"title":"IN VIVO PROTEKTIVNI EFEKAT EKSTRAKATA BILJKE Lysimachia vulgaris NA DNK OŠTEĆENJA INDUKOVANA ETIL METANSULFONATOM 2022ЗБОРНИК БИОДИВЕРЗИТЕТ","authors":"S. Matić, N. Srećković, Jelena Katanić Stanković, V. Mihailović","doi":"10.46793/sbt27.523m","DOIUrl":null,"url":null,"abstract":"The in vivo genotoxic activity of the aerial part and root methanol extracts of Lysimachia vulgaris L. and ability to protect DNA from ethyl methanesulfonate- induced DNA damage was studied using comet assays in Drosophila melanogaster. Results revealed no significant differences in mean genetic damage index between exposure groups (20, 40, 80 mg mL-1 of Drosophila food) and negative control, indicating a non-genotoxic effect. Combined treatment of extracts and ethyl methanesulfonate showed a significant reduction in DNA damage with a percentage of reduction above 80. These findings suggest that the methanolic extract of L. vulgaris could be used as a natural agent in the prevention of diseases associated with DNA damage.","PeriodicalId":212864,"journal":{"name":"Zbornik radova / XXVII savetovanje o biotehnologiji sa međunarodnim učešćem","volume":"104 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zbornik radova / XXVII savetovanje o biotehnologiji sa međunarodnim učešćem","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46793/sbt27.523m","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The in vivo genotoxic activity of the aerial part and root methanol extracts of Lysimachia vulgaris L. and ability to protect DNA from ethyl methanesulfonate- induced DNA damage was studied using comet assays in Drosophila melanogaster. Results revealed no significant differences in mean genetic damage index between exposure groups (20, 40, 80 mg mL-1 of Drosophila food) and negative control, indicating a non-genotoxic effect. Combined treatment of extracts and ethyl methanesulfonate showed a significant reduction in DNA damage with a percentage of reduction above 80. These findings suggest that the methanolic extract of L. vulgaris could be used as a natural agent in the prevention of diseases associated with DNA damage.
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