Syndrome Z and Its Association with Obstructive Sleep Apnea

G. Hassan, W. Qureshi
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Abstract

It is clear that obstructive sleep apnea (OSA) and metabolism syndrome share a similar pathophysilogic milieu that would be expected to increase the risk of cardiovascular disease. In patients with established coronary artery disease, treatment of OSA may confer long term cardiovascular benefits. Prevention of nocturnal hypoxemia, sympathetic activation and pressor surges in addition to reduction of daytime sympathetic activity, blood pressure and insulin resistance by continuous positive airway pressure would improve cardiovascular outcomes in patients with metabolic syndrome.
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Z综合征及其与阻塞性睡眠呼吸暂停的关系
很明显,阻塞性睡眠呼吸暂停(OSA)和代谢综合征具有相似的病理生理环境,预计会增加心血管疾病的风险。对于已确诊冠状动脉疾病的患者,OSA的治疗可能会带来长期的心血管益处。通过持续气道正压治疗预防夜间低氧血症、交感神经激活和血压升高,以及减少白天交感神经活动、血压和胰岛素抵抗,将改善代谢综合征患者的心血管结局。
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