D. Sosnin, A. Shchekotova, L. S. Pavlenina, P. D. Piniagina
{"title":"CASE OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA. PROBLEMS OF LABORATORY DIAGNOSTICS","authors":"D. Sosnin, A. Shchekotova, L. S. Pavlenina, P. D. Piniagina","doi":"10.14489/lcmp.2022.04.pp.037-050","DOIUrl":null,"url":null,"abstract":"The presented case demonstrates the importance of a comprehensive analysis of all the examination data in a patient with paroxysmal nocturnal hemoglobinuria (PNH). A comparison was made of anamnesis data, the clinical picture of the disease, the results of biochemical blood analysis and hematological analyzer data with morphological assessment of cells in a stained blood smear. The interest of this case for hematologists and laboratory specialists is due to the rarity of this disease, difficulties in diagnostics, the presence of 2 types of hemolysis, features of morphological changes in peripheral blood erythrocytes, as well as analysis of the dynamics of manifestations, including against the background of targeted therapy of PNH.","PeriodicalId":287737,"journal":{"name":"Laboratornaya i klinicheskaya meditsina. Farmatsiya","volume":"8 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratornaya i klinicheskaya meditsina. Farmatsiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14489/lcmp.2022.04.pp.037-050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The presented case demonstrates the importance of a comprehensive analysis of all the examination data in a patient with paroxysmal nocturnal hemoglobinuria (PNH). A comparison was made of anamnesis data, the clinical picture of the disease, the results of biochemical blood analysis and hematological analyzer data with morphological assessment of cells in a stained blood smear. The interest of this case for hematologists and laboratory specialists is due to the rarity of this disease, difficulties in diagnostics, the presence of 2 types of hemolysis, features of morphological changes in peripheral blood erythrocytes, as well as analysis of the dynamics of manifestations, including against the background of targeted therapy of PNH.
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