Relevancia clínica de la codetección viral en lactantes con bronquiolitis por virus respiratorio sincitial

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-06-01 DOI:10.1016/j.eimc.2023.04.009

Albert Bernet Sánchez , Alba Bellés Bellés , Mercè García González , Laura Minguell Domingo , Eduard Solé Mir

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Abstract

Introduction

Respiratory syncytial virus (RSV) is the main cause of severe bronchiolitis, especially in infants. The aim of this study is to assess whether codetection of RSV and other respiratory viruses could affect the severity of this infection comparing with unique RSV detection.

Methods

A prospective study from 2016 to 2019 including children under 2 years who were admitted in the Emergency Service of the Hospital Universitari Arnau de Vilanova de Lleida (Spain) was performed. Nasopharyngeal samples from all patients were sent to the laboratory for RSV real-time PCR detection (GeneXpert®). A multiplex PCR that detects other respiratory viruses was done in all RSV-positive samples. Patients’ medical records were checked to collect clinical data (hospital length of stay, BROSJOD score, ICU admission, need for ventilatory support or transfer to a reference hospital). Patients were divided in 2 groups: infants with unique RSV detection and infants with viral codetection. Bivariant analyses were performed to analyze the data obtained.

Results

During the period of study 437 RSV bronchiolitis were diagnosed. In 199 of them (177/437; 45.5%) another respiratory virus was detected concomitantly. Bivariant analyses do not show statistically significant differences between both groups.

Conclusions

Viral codetection in infants with RSV bronchiolitis is frequent. However, it does not seems to affect the severity of this infection.

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呼吸道合胞病毒支气管炎婴儿合并病毒检测的临床意义

导言呼吸道合胞病毒（RSV）是导致严重支气管炎的主要原因，尤其是在婴儿中。本研究的目的是评估与单独检测 RSV 相比，RSV 和其他呼吸道病毒的编码检测是否会影响这种感染的严重程度。方法从 2016 年到 2019 年进行了一项前瞻性研究，研究对象包括在西班牙阿瑙-德-比拉诺瓦-德-莱里达大学医院急诊科住院的 2 岁以下儿童。所有患者的鼻咽部样本都被送往实验室进行 RSV 实时 PCR 检测（GeneXpert®）。在所有 RSV 阳性样本中还进行了检测其他呼吸道病毒的多重 PCR 检测。检查患者病历以收集临床数据（住院时间、BROSJOD 评分、入住重症监护室、呼吸机支持需求或转入参考医院）。患者分为两组：检测到唯一的 RSV 的婴儿和检测到病毒编码的婴儿。研究期间共诊断出 437 例 RSV 支气管炎。其中 199 例（177/437；45.5%）同时检测到另一种呼吸道病毒。双变量分析未显示两组之间存在显著的统计学差异。然而，这似乎并不影响感染的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.