Enfermedades infecciosas y microbiologia clinica最新文献

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Lung cancer screening in people with HIV: A missed opportunity for better outcomes? 艾滋病病毒感染者的肺癌筛查：错失改善疗效的良机？

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.12.005

Mar Masiá , Félix Gutiérrez

引用次数: 0

Uncommon lip lesions in an HIV individual 艾滋病毒感染者罕见的唇部病变

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.06.017

Diego Ulises Vázquez Omaña , Roxana Claudia Iquize Condori , Ariel García Torralba , Miguel Ángel Martínez Rojas , Pamela Monserrat Vidales Higuera , Alvaro López Iñiguez

引用次数: 0

Endocarditis infecciosa por Achromobacter xylosoxidans después de implante de válvula aórtica percutánea: a propósito de un caso

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.11.004

Amparo Buforn Pascual , José Albors Martín , Coral Llopis Ruiz , Adriana Hernández Belmonte

引用次数: 0

Programa de profilaxis pre-exposición de la Comunidad de Madrid: 2 años de experiencia 马德里社区的接触前预防计划：两年的经验。

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.03.014

Nuria Fernández Piñeiro , Oskar Ayerdi Aguirrebengoa , Eva Orviz García , Cristina González Pérez , Mar Vera García , Teresa Puerta López , Carmen Rodríguez Martín , Clara Lejarraga Cañas , Jorge Perez García , Begoña Baza Caraciolo , Monserrat González Polo , Florentina Alcudia Pérez , Marta Ruiz Fernández , Natividad Jerez Zamora , Diego Morales Irala , Beatriz López Centeno , Daniele Alioto , José Manuel Martínez Sesmero , Vicente Estrada Pérez , María Teresa Benítez Gimenez , Jorge del Romero Guerrero

Introduction

Pre-exposure prophylaxis (PrEP) against the human immunodeficiency virus (HIV) is an effective and safe preventive measure. However, it has not reached all target users who could benefit from it.

The study aimed to understand the sociodemographic, clinical and behavioral baseline characteristics of PrEP users. As a secondary objective, the use of concomitant medication and drug consumption were described.

Methodology

Observational, retrospective and descriptive study of the sociodemographic, clinical and behavioral characteristics of the users who were included in the PrEP program of the Community of Madrid during the first two years of experience.

Results

Two thousand two hundred fifty-six PrEP users were included, 99.0% men, with a mean age of 36.9 years (SD: 8.68). 33.1% presented a sexually transmitted infection (STI) on the first visit, highlighting chlamydiasis and rectal gonococci. 70.4% reported using drugs associated with sex, and 42.4% participated in chemsex sessions in the last 3 months. A high percentage of users with concomitant medication was observed (37.6%), highlighting drugs related to mental health and alopecia.

Conclusions

A multidisciplinary approach is required to cover all the needs of PrEP users, including mental health evaluation measures and addiction treatment with the clinical approach.

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引用次数: 0

Prevalence and antimicrobial susceptibility profile of Corynebacterium glucuronolyticum in genitourinary tract samples

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.10.007

Ana Cotos Suárez, Fernando García-Garrote, Laura Sancha Domínguez, Ana María Blázquez de Castro, María del Mar Collado Llano, Eva María Lorenzo Iglesias

Introduction

Corynebacterium glucuronolyticum (C. glucuronolyticum) is a species recently recognized as a potential pathogen of the male genitourinary tract. The objective is to determine the prevalence of C. glucuronolyticum in genitourinary tract samples as well as their antimicrobial susceptibility profile.

Methods

A prospective study was conducted from 1st of November 2021 to the 30th of November 2022, for all genitourinary tract samples collected from male patients with suspicion of balanitis, prostatitis and urethritis. Antimicrobial susceptibility testing was performed in all C. glucuronolyticum isolates.

Results

A total of 73 C. glucuronolyticum isolates from 693 clinical specimens were obtained. This represents an overall C. glucuronolyticum prevalence of 10.5%. All strains were susceptible to vancomycin, linezolid and rifampicin, whereas 94%, 68% and 65% were resistant to clindamycin, tetracycline and ciprofloxacin, respectively.

Conclusion

Clinical microbiology laboratories should perform antimicrobial susceptibility testing against C. glucuronolyticum due to the significant rate of resistance to ciprofloxacin and tetracycline.

{"title":"Prevalence and antimicrobial susceptibility profile of Corynebacterium glucuronolyticum in genitourinary tract samples","authors":"Ana Cotos Suárez, Fernando García-Garrote, Laura Sancha Domínguez, Ana María Blázquez de Castro, María del Mar Collado Llano, Eva María Lorenzo Iglesias","doi":"10.1016/j.eimc.2024.10.007","DOIUrl":"10.1016/j.eimc.2024.10.007","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Corynebacterium glucuronolyticum</em> (<em>C. glucuronolyticum</em>) is a species recently recognized as a potential pathogen of the male genitourinary tract. The objective is to determine the prevalence of <em>C. glucuronolyticum</em> in genitourinary tract samples as well as their antimicrobial susceptibility profile.</div></div><div><h3>Methods</h3><div>A prospective study was conducted from 1st of November 2021 to the 30th of November 2022, for all genitourinary tract samples collected from male patients with suspicion of balanitis, prostatitis and urethritis. Antimicrobial susceptibility testing was performed in all <em>C. glucuronolyticum</em> isolates.</div></div><div><h3>Results</h3><div>A total of 73 <em>C. glucuronolyticum</em> isolates from 693 clinical specimens were obtained. This represents an overall <em>C. glucuronolyticum</em> prevalence of 10.5%. All strains were susceptible to vancomycin, linezolid and rifampicin, whereas 94%, 68% and 65% were resistant to clindamycin, tetracycline and ciprofloxacin, respectively.</div></div><div><h3>Conclusion</h3><div>Clinical microbiology laboratories should perform antimicrobial susceptibility testing against <em>C. glucuronolyticum</em> due to the significant rate of resistance to ciprofloxacin and tetracycline.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 162-164"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neumonía neonatal de mala evolución: un agente insospechado

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.10.003

Judith Lozano González, Alba de Tíscar Sánchez García

引用次数: 0

Parvovirus B19 and central nervous system: A case series

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.10.005

Luis Gago , Elvira Baos , Mercedes Martínez-Rodríguez , Alberto Delgado-Iribarren

引用次数: 0

Antimicrobial resistance and epidemiological aspects of Neisseria gonorrhoeae in the province of Lleida, Spain (2017–2024)

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.06.016

Alejandro Cumplido , Jesús Aramburu , María Font , Marina Montes , Raquel Abad , Eric López , Albert Bernet , Saray Mormeneo , Iván Prats , Mercè García , Elena Sánchez , Alba Bellés

Introduction

Neisseria gonorrhoeae (NG) is one of the main causes of sexually transmitted infections and it is reaching high resistance levels worldwide. The aim of this study was to describe the antibiotic resistance, incidence and circulating sequence types of NG in the province of Lleida (Spain).

Methods

A total of 487 NG isolates were included in the study (2017–2024). Antibiotic susceptibility testing was performed by gradient diffusion following EUCAST criteria. NG-MAST was performed to 211 isolates in Centro Nacional de Microbiología (Majadahonda, Spain). The study of co-infections was done by real-time PCR (Allplex™ STI, Seegene®).

Results

All NG isolates remained susceptible to third-generation cephalosporins. The percentages of resistance to tetracycline, ciprofloxacin and penicillin G were 89.1%, 69.2% and 22.6% respectively. A 7.8% of isolates presented a MIC >1 mg/L for azithromycin. A decrease in the incidence of gonococcal infections was detected during 2020, followed by a pronounced increase in next years. Ninety-seven different sequence types were detected. ST14994 (14.7%) and ST19792 (6.6%), were the most frequent ST detected in our study. NG appeared as a single STI agent in most cases (77.7%) and Chlamydia trachomatis was the most frequently detected STI agent (74.8%) in samples with co-infections.

Conclusions

NG incidence is increasing in our area. The lack of resistance to third-generation cephalosporins and the low level of azithromycin resistance suggest that the use of these antibiotics is a suitable option. Continuous surveillance is essential to prevent the emergence and spread of resistant NG isolates.

导言淋病奈瑟菌（NG）是性传播感染的主要病原体之一，在全球范围内的耐药性水平都很高。本研究旨在描述莱里达省（西班牙）NG的抗生素耐药性、发病率和循环序列类型。研究共纳入487株NG分离株（2017-2024年）。抗生素药敏试验按照欧盟抗生素药敏试验（EUCAST）标准通过梯度扩散法进行。在国家微生物中心（西班牙马亚达洪达）对211个分离株进行了NG-MAST检测。通过实时 PCR（Allplex™ STI，Seegene®）对合并感染进行了研究。对四环素、环丙沙星和青霉素 G 的耐药率分别为 89.1%、69.2% 和 22.6%。7.8%的分离菌株对阿奇霉素的 MIC 值为 1 mg/L。在 2020 年期间，淋球菌感染的发病率有所下降，随后几年则明显上升。检测到 97 种不同的序列类型。ST14994（14.7%）和ST19792（6.6%）是本研究中最常检测到的ST。在大多数病例（77.7%）中，NG是单一的性传播感染病原体，而在合并感染的样本中，沙眼衣原体是最常检测到的性传播感染病原体（74.8%）。第三代头孢菌素缺乏耐药性，而阿奇霉素的耐药性较低，这表明使用这些抗生素是一种合适的选择。持续监测对于防止耐药 NG 分离物的出现和传播至关重要。

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引用次数: 0

Effectiveness of Mycobacterium tuberculosis recombinant proteins-coated gold nanoparticles in improving the interferon-gamma release assay test

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.06.015

Najmeh Jomehpour , Mojtaba Sankian , Saman Soleimanpour , Mohammad Derakhshan , Kiarash Ghazvini , Safora Pordel , Malihe Moghadam

Introduction

Gold nanoparticles (GNPs) are chemically inert, have low toxicity, and are easy to modify and functionalize for the detection of many pathogens. They have excellent immune modulatory and adjuvant properties. The aim of this study was to improve the diagnosis of latent tuberculosis infection (LTBI) by adding GNPs in tests based on interferon-gamma (IFN-γ) measurement.

Methods

GNPs were coated with Mycobacterium tuberculosis (Mtb) recombinant proteins including TB10.4, CFP-10, ESAT-6, and TB7.7. Then, they exposed the whole blood of subjects with active tuberculosis (aTB), LTBI, and healthy controls (HC). Subsequently, IFN-γ produced in GNP tubes (QFT-NG) was measured and compared with IFN-γ produced in tubes without GNPs [QFT-A: (CFP-10, ESAT-6, TB7.7, TB10.4), QFT-B: (CFP-10, ESAT-6, TB7.7)].

Results

The results showed that the IFN-γ production in the GNPs tubes was significantly higher than in tubes without GNPs in aTB, LTBI, and HC subjects. In aTB patients, the mean difference (MD) between the QFT-NG and QFT-A tubes was 0.44, with a P-value of 0.04, and a 95% CI: 0.07–0.88. Furthermore, in LTBI individuals, the QFT-NG and QFT-A tubes exhibited an MD = 0.21, P-value = 0.03, 95% CI: 0.15–0.4. In the aTB and LTBI subjects were detected in the QFT-NG tubes with a sensitivity of 95%, 100% and specificity 100%, 86%, respectively.

Conclusion

The use of GNPs coated with Mtb recombinant proteins can aid in detecting LTBI subjects by increasing IFN-γ levels.

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引用次数: 0

An exceptional cause of brain abscess

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-03-01 DOI: 10.1016/j.eimc.2024.09.011

Sofía De la Villa , Verónica Parras , Leire Pérez-Latorre , Pablo Martín-Rabadán

引用次数: 0

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