{"title":"Adaptive Designs","authors":"G. Wassmer, F. Koenig, Martin Posch","doi":"10.1201/9781315119694-17","DOIUrl":null,"url":null,"abstract":"Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"49 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Handbook of Statistical Methods for Randomized Controlled Trials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1201/9781315119694-17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.
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