{"title":"Count Data","authors":"Xin He, J. Sun","doi":"10.1201/9781315119694-5","DOIUrl":"https://doi.org/10.1201/9781315119694-5","url":null,"abstract":"","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114284655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.1201/9781315119694-17
G. Wassmer, F. Koenig, Martin Posch
Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.
{"title":"Adaptive Designs","authors":"G. Wassmer, F. Koenig, Martin Posch","doi":"10.1201/9781315119694-17","DOIUrl":"https://doi.org/10.1201/9781315119694-17","url":null,"abstract":"Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121301328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.1201/9781315119694-14
Sin-Ho Jung
{"title":"Sample Size Estimation and Power Analysis: Longitudinal Data","authors":"Sin-Ho Jung","doi":"10.1201/9781315119694-14","DOIUrl":"https://doi.org/10.1201/9781315119694-14","url":null,"abstract":"","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131679142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.1201/9781315119694-12
Joanne C. Rothwell, C. Cooper, S. Julious, Michael Campbell
{"title":"Background to Sample Size Calculations","authors":"Joanne C. Rothwell, C. Cooper, S. Julious, Michael Campbell","doi":"10.1201/9781315119694-12","DOIUrl":"https://doi.org/10.1201/9781315119694-12","url":null,"abstract":"","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128330981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Binary and Ordinal Outcomes","authors":"G. M. Fitzmaurice, S. Lipsitz","doi":"10.1201/9781315119694-2","DOIUrl":"https://doi.org/10.1201/9781315119694-2","url":null,"abstract":"","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128925562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.1007/978-1-4419-9863-7_100791
Soeun Kim, M. Paik
{"title":"Longitudinal Data","authors":"Soeun Kim, M. Paik","doi":"10.1007/978-1-4419-9863-7_100791","DOIUrl":"https://doi.org/10.1007/978-1-4419-9863-7_100791","url":null,"abstract":"","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129010428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.1201/9781315119694-13
O. Bautista, K. Anderson
{"title":"Sample Size Estimation and Power Analysis: Time to Event Data","authors":"O. Bautista, K. Anderson","doi":"10.1201/9781315119694-13","DOIUrl":"https://doi.org/10.1201/9781315119694-13","url":null,"abstract":"","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117000463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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