İkinci-Üçüncü Trimesterde Aspartat Aminotransferaz Trombosit Oranı İndeksinin Gebeliğin İntrahepatik Kolestazı Öngörmesi ve İndeksin Yenidoğan Yoğun Bakım Gereksinimi ile İlişkisi: Üçüncü Basamak Bir Hastaneden Vaka Kontrol Çalışması

Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi Pub Date : 2023-07-23 DOI:10.38136/jgon.1231865

Bedri Sakcak, Ramazan Deni̇zli̇, Nihat Fari̇soğullari, Göksun İpek, Özgür Kara, Atakan Tanacan, Dilek Sahi̇n

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Abstract

Aim: To evaluate the aspartate aminotransferase platelet ratio index (APRI) score in the prediction of intrahepatic cholestasis (ICP) in the second-third trimester of pregnancy. Material and Methods: The patient group (n=40) and control group (n=70) diagnosed with ICP who applied to the hospital Perinatology clinic between 2021-2022 were included in this study. Laboratory tests of both groups were analyzed retrospectively. Age, gravida, parity, body mass index, third trimester laboratory tests and first trimester aspartate aminotransferase (AST)/platelet count ratio [AST - platelet ratio index (APRI) score] APRI scores were compared between the two groups. The relationship between APRI score index and neonatal outcomes was evaluated in the study group.In the study, the cut-off value of the APRI score was determined for predicting ICP in second-third trimester in pregnant women. Results: Patients with ICP had significantly higher APRI scores compared with controls (p

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目的:探讨天冬氨酸转氨酶血小板比值指数(APRI)评分对妊娠中晚期肝内胆汁淤积症(ICP)的预测价值。材料与方法:选取2021-2022年在医院围产儿门诊就诊的ICP患者组(n=40)和对照组(n=70)为研究对象。回顾性分析两组患者的实验室检查结果。比较两组患者的年龄、妊娠、胎次、体重指数、妊娠晚期实验室检查及妊娠早期天冬氨酸转氨酶(AST)/血小板计数比值[AST -血小板比值指数(APRI)评分]APRI评分。评估研究组APRI评分指数与新生儿结局的关系。在这项研究中，APRI评分的临界值被确定为预测妊娠中晚期ICP的指标。结果:ICP患者APRI评分明显高于对照组(p

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Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi

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