Physiological Bases of Electric Stimulation as a New Approach to Glaucoma IOP Control

L. Nino-de-Rivera, Diego Cervera, Paola Castillo-Juárez
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Abstract

This Chapter focuses in the electrophysiological bases to support Trans Palpebral Electrical Stimulation TPES as a new alternative to control Intraocular Pressure IOP. Primary open Angle Glaucoma POAG is described in our approach as a dysfunction of the membrane potential of TM cells due to the dysfunction of the Maxi potassium depended Calcium Channels BKCa2+ of the Trabecular Mesh TM. We review through the paper the main contributions about Trabecular mesh dysfunction related with Voltage dependent ionic channels. We also present in this paper new results in controlling intra ocular pressure IOP during one year of trans palpebral Electric stimulation in patients with Primary open-angle glaucoma (POAG).
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电刺激控制青光眼IOP新方法的生理基础
本章重点介绍支持经眼睑电刺激TPES作为控制眼压IOP的新选择的电生理基础。原发性开角型青光眼POAG在我们的方法中被描述为由于小梁网TM的Maxi钾依赖钙通道BKCa2+功能障碍而导致的TM细胞膜电位功能障碍。本文综述了与电压依赖性离子通道相关的小梁网功能障碍的主要研究成果。本文还报道了经睑电刺激治疗原发性开角型青光眼(POAG)患者一年时间内控制眼压IOP的新结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Physiological Bases of Electric Stimulation as a New Approach to Glaucoma IOP Control Retinal Vascular Implications of Ocular Hypertension
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