Jianzhi Deng, Yuehan Zhou, Xiaohui Cheng, Tianyu Li, C. Qin
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引用次数: 0
Abstract
In our research, we try to find out the Competing Endogenous RNA Network (ceRNA) and the biomarker of Liver cancer (LC). 490 differentially expressed mRNAs, 248 differentially expressed lncRNAs and 66 differentially expressed miRNAs were screened from the TCGA liver data. Among then, the differentially expressed mRNAs were enriched in 88 biological process, 16 cellular component and 27 molecular function of the gene ontology. And they were mostly enriched in extracellular region, extracellular space, integral component of plasma membrane, regulation of transcription and DNA-templated sequence-specific DNA binding. 14 DElncRNAs, 11 DEmiRNAs and 4 DEmRNAs were built the ceRNA network based on their inter-regulatory. The up-regulated mRNA in liver tumor samples, CCNE1, was regard as the biomarker of liver cancer by the proof of survival analysis and receiver operating characteristic analysis.
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