Lyophilized extract of Hibiscus Sabdariffa L. induces cytotoxicity in breast cancer cell lines.

Abstract

: Some types of cancer are resistant to conventional treatments, such as triple-negative (TN) breast cancer (BC), which, due to its molecular characteristics, does not respond effectively. In recent years, there has been an increase in the use of medicinal plants for prevention and as an alternative in adjuvant therapy for cancer. Hibiscus sabdariffa L. (H.S.) is a plant which has anti-inflammatory and antioxidants properties. The objective of this study is to evaluate the cytotoxicity effect of the lyophilized extract of H.S. in the TN BC cell line (HCC-70) exposed to different concentrations (0.10, 0.25, 0.5 and 1.0 mg/mL). The results were evaluated by ANOVA, finding that H.S. reduces the proliferation on TN BC cell line HCC-70 exposed at 1.0 mg/mL by 62%. The use of natural extracts as coadjuvant therapy for cancer is an alternative with great potential for future studies and provides a precedent in the area of natural medicine.