ANTIPROLIFERATIVE EFFECTS OF SOME MEDICINAL PLANTS ON COLORECTAL CANCER: A MINI REVIEW

BAU Journal - Health and Well-Being Pub Date : 2022-10-30 DOI:10.54729/bsla1133

J. Borjac

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Abstract

Colorectal cancer (CRC) is one of the highly prevalent and deadly cancers worldwide. Surgery, chemotherapy and radiotherapy are the conventional treatment modalities for CRC; however, they cause adverse side effects and can be associated with cancer resistance and relapse. Currently, traditional herbal medicine is becoming increasingly studied and used in combination with conventional treatments in CRC. Various medicinal plants have shown promising anticancer effects against CRC concomitant with negligible side effects. For example, Annona muricata (soursop), Chenopodium quinoa (quinoa), Matricaria chamomilla (chamomile), and Moringa oleifera (moringa) have shown remarkable antiproliferative effects against CRC both in vitro and in vivo. Therefore, it is warranted to document the recuperative role of these potential medicinal plants in CRC. It is also important to provide scientific explanations for these effects by establishing their effects on key signaling pathways implicated in colorectal carcinogenesis. In this review, a summary of key signaling pathways that are altered in CRC is presented. The antiproliferative effects of selected medicinal plants against CRC as well as their underlying mechanisms of action are also discussed.

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一些药用植物对结直肠癌的抗增殖作用综述

结直肠癌(CRC)是世界范围内高发和致命的癌症之一。手术、化疗和放疗是结直肠癌的常规治疗方式;然而，它们会引起不良的副作用，并可能与癌症抵抗和复发有关。目前，越来越多的研究和应用传统草药与常规治疗联合治疗结直肠癌。多种药用植物对结直肠癌具有良好的抗癌作用，且副作用很小。例如，番荔枝(Annona muricata)、藜麦(Chenopodium quinoa)、洋甘菊(Matricaria chamomilla)和辣木(Moringa oleifera)在体外和体内均显示出显著的抗CRC增殖作用。因此，有必要记录这些潜在药用植物在结直肠癌中的恢复作用。通过确定它们对结直肠癌发生过程中涉及的关键信号通路的影响，为这些影响提供科学解释也很重要。在这篇综述中，综述了CRC中发生改变的关键信号通路。本文还讨论了部分药用植物对结直肠癌的抗增殖作用及其作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BAU Journal - Health and Well-Being

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