Juvenile Ovarian Granulosa Cell Tumor - A Case Report

Abstract

The granulosa cell tumor is an unusual ovarian tumor, even more so in pediatric age. The literature indicates that the prevalence and the incidence is more higher in patients after the fifth decade of the life with a frequency of 3.4 % of all ovarian malignancies, since most of them correspond to the benign pathologies. The tumor produces symptoms derived from the secretion of the estradiol. The granulosa cell tumor has been described as better prognosis, less aggressive than other ovarian neoplasms and the natural history was longer. Surgery is the main diagnostic, staging and therapeutic approach. The adjuvant chemotherapy is recommended only in the early stages with risk factors or in the advanced stages, as it can improve disease-free and relapse-free survival rates, such as radiation therapy. So far, the most commonly used regimens are bleomycin, etoposide, and cisplatin, with a high reaction rate. Whenever possible, surgical rescue is proposed.