Normal conversion of thyroxine to triiodothyronine in a subject with iodotyrosine-dehalogenase deficiency.

Pahlavi medical journal Pub Date : 1976-10-01
F Ismail-Beigi, M Rahimifar
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Abstract

BMR, t1/2 of serum T4, and the conversion of T4 to T3 were normal in a patient with iodotyrosine-dehalogenase deficiency who had undergone total surgical thyroidectomy and had been maintained on 200 mug of oral T4 daily. It is concluded that the enzyme system for monodeiodination and conversion of T4 to T3 is different than iodotyrosine-dehalogenase.

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碘酪氨酸-去卤酶缺乏症患者甲状腺素向三碘甲状腺原氨酸的正常转化。
1例碘酪氨酸-去卤素酶缺乏症患者行甲状腺全切除术,维持每日口服T4 200杯,BMR、血清T4 t1/2、T4向T3转化正常。综上所述,单脱碘和T4到T3转化的酶系统与碘酪氨酸-脱卤酶不同。
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