Systematic identification of local structure binding motifs in protein-RNA recognition

Abstract

Many critical biological processes are strongly related to protein-RNA interactions. Revealing the structure motifs of performing protein-RNA binding function will provide valuable information for deciphering their interaction mechanisms and benefit complementary structure designs in bioengineering. In this work, we provide a study of systematic identification of protein structure motifs of RNA-binding sites in form of pockets on protein surfaces by clustering these local structure patterns into similar groups. We also identify the crucial recognition patterns and the structural complementary features in the protein-RNA binding events.