A Comparative Evaluation of Mycobacterium w Vaccine Based Immunotherapy plus Concomitant Chemoradiation versus Concomitant Chemoradiation alone in Locally Advanced Head and Neck Cancer

Abstract

Head and neck cancer (HNC) including lip, oral cavity, nasopharynx, other pharynx and larynx is the 7 th most common cancer globally. The incidence wise male-female ratio for HNC is nearly 3.7: 1 in India and nearly 2.7:1 globally [1].An increase in incidence of HNC (squamous cell carcinoma) is observed with increase in age and usually presents after 40 years of age [2]. Most of the head and neck cancers are triggered by alcohol and tobacco, which together probably account for three-quarters of cases [3].Tobacco smoking is associated with increased risk for all of the more common forms of HNC, the risk among cigarette smokers may be ten or more times than that for non-smokers [4,5].