Immunological membrane markers of Hodgkin's cells.

M E Kadin, S Gold, E M Garratty, D P Stites
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引用次数: 6

Abstract

Reed-Sternberg and other Hodgkin's giant cells derived from involved spleens and lymph nodes of patients with Hodgkin's disease were examined for surface markers of T and B cells and macrophages. Attachment and phagocytosis of untreated (E) or sensitized (EA and EAC) sheep red blood cells and yeast by Reed-Sternberg cells did not occur. IgG frequently detected at the membrane of Reed-Sternberg cells was partially removed by incubation and washing at 37 degrees C. Fluorescence with a specific anti-T cell serum was not seen on Reed-Sternberg and other Hodgkin's giant cells lack most detectable normal human lymphoid cell markers, but do exhibit membrane bound immunoglobulin possibly of exogenous origin.

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霍奇金细胞的免疫膜标记物。
Reed-Sternberg和其他霍奇金巨细胞来源于霍奇金病患者受损伤的脾脏和淋巴结,检测T细胞、B细胞和巨噬细胞的表面标记物。未处理(E)或致敏(EA和EAC)羊红细胞和酵母未发生Reed-Sternberg细胞的附着和吞噬。在Reed-Sternberg细胞膜上经常检测到的IgG通过37℃孵卵和洗涤部分去除,在Reed-Sternberg细胞和其他霍奇金巨细胞上未见带有特异性抗t细胞血清的荧光,缺乏大多数可检测的正常人类淋巴样细胞标记物,但确实表现出可能来自外源性的膜结合免疫球蛋白。
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