Voltammetric determination of paracetamol at glycine modified carbon paste electrode

Y. Yohannes, Aragaw Nega Mekonnen, Mekuriaw Assefa
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引用次数: 1

Abstract

The lower body tolerance of paracetamol (PCT) is 50 ppm and if it surpasses; PCT will led to accumulation of toxic metabolites. A carbon paste electrode modified with glycine (GlyCPE) is used for the detection of PCT at relatively low concentrations. In contrast to the bare carbon paste electrode (CPE), an improved onset potential with a shifting of 85 mV and enhancement of anodic peak current at the modified electrode resulted in a the GlyCPE surface with a material that possesses an electroanalytical activity toward the oxidation of PCT. Differential pulse stripping voltammograms (DPSV) of PCT oxidation on the GlyCPE yielded a well-defined oxidation peak of 0.61 V in a 0.1 M phosphate buffer solution of pH 6.0 with a linear calibration from 5.0 to 1000 mM with R2 = 0.995. The DPSV detection limit was projected to be 0.12 mM. In the presence of the interfering ascorbic acid (AA) of 50 and 100 mM, the GlyCPE was able to detect the PCT (100 mM) with a percentage of detection of 100.16 and 97.79, respectively, which did not affect significantly the peak current response of the PCT. Besides, the fabricated GlyCPE accurately measured the amount of PCT in three brand pharmaceutical samples.
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甘氨酸修饰碳糊电极伏安法测定扑热息痛
对乙酰氨基酚(PCT)的下半身耐受量为50ppm,如果超过;PCT会导致有毒代谢物的积累。用甘氨酸修饰的碳糊电极(GlyCPE)用于检测相对低浓度的PCT。与裸碳糊电极(CPE)相比,改进出现潜在的转移85 mV和增强改性电极的阳极峰电流导致GlyCPE表面材料,拥有一个electroanalytical活动对PCT的氧化。微分脉冲剥离voltammograms (DPSV) PCT氧化GlyCPE产生一个定义良好的氧化峰的0.61 V 0.1米磷酸缓冲溶液的pH值6.0线性校准从5.0到1000毫米,R2 = 0.995。预测DPSV检出限为0.12 mM,在抗坏血酸(AA)干扰50和100 mM的情况下,GlyCPE对PCT (100 mM)的检出率分别为100.16和97.79,对PCT的峰值电流响应无明显影响,且制备的GlyCPE能准确测定3个品牌药品样品中PCT的含量。
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