An experimental study on treating newborn rats with hypoxic ischemic encephalapathy with fonzylane

Abstract

Objective To observe the effects of fonzylane on newborn rats with hypoxic ischemic encephalopathy (HIE) and search for an effective therapy to deal with HIE. Methods Models of newborn rats with HIE were established, and 104 rats were devided into 13 groups. After treatment with fonzylane, the blood perfusion, pathology, arachidonic acid content, free radical clearance, and metabolism of intracellular free calcium in the brain of rats were investigated. Results Carotid arterial blood pressures of rats were not different before and after applying fonzylane. The arteriolae of the soft meninges of ischemic cerebral hemisphere were dilated by 18.6% ~ 22.7 %, which were two times more than those of the other normal cerebral hemisphere; the blood circulation was also significantly accelerated; both the ratio of TXB2/PGI2 and the content of the endocellular free calcium decreased; but the SOD activity of cerebrum increased. The neurocytes were observed almost recovered under the electronmicroscope. Conclusion The blood perfusion of the ischemic region of cerebrum could be significantly recovered by using fonzylane. There was no intracerebral steal phenomenon. In the mean time fonzylane, as a mild calcium antagonist and activitor of SOD, could reduce or might avoid the reperfusion damage. The results indicated that further clinical investigations on the treatment of HIE neonates with Fonaylane are needed. Key words: Rats; Cerebral anoxia; Cerebral ischemia; Pyrrolidines